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10.7150/jca.19873 http://scihub22266oqcxt.onion/10.7150/jca.19873 C5595093!5595093!28900501     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cancer 2017 ; 8 (13): 2636-42 Nephropedia Template TP {{tp|p=28900501|t=2017. Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase |pdf=|usr=}}{{28900501}} gab.com Text Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase JO: J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28900501 #FOAvip Vincristine is extensively used chemotherapeutic medicine to treat leukemia. However, it remains a critical clinical problem with regard to its toxicity and drug-resistance. AMP-activated protein kinase (AMPK) is an energy sensor that is pivotal in maintaining cell metabolic homeostasis. It is reported that AMPK is involved in vincristine-induced apoptosis. However, whether AMPK is involved in chemotherapy-resistance is largely unclear. It is well-documented that metformin, a widely used medicine to treat type II diabetes, possesses anti-cancer activities, yet whether metformin affects leukemia cell viability via vincristine is unknown. In this study, we showed that both AMPK?1 mRNA and phosphorylated AMPK protein levels were significantly decreased in clinical leukemia samples. We further demonstrated that metformin sensitized leukemia cells to vincristine-induced apoptosis in an AMPK-dependent manner. In addition, knockdown of AMPK?1 significantly reduced the effects of metformin on vincristine-induced apoptosis. Taken together, these results indicate that AMPK activation is critical in metformin effects on vincristine-induced apoptosis and suggest a putative strategy of a combination therapy using metformin and vincristine in treatment of leukemia. Twit Text FOAVip Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase ????J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28900501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28900501 #FOAvip English Wikipedia <ref>{{Cite pmid|28900501}}</ref> Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase #MMPMID28900501 Yi Y; Gao L; Wu M; Ao J; Zhang C; Wang X; Lin M; Bergholz J; Zhang Y; Xiao ZXJ J Cancer 2017[]; 8 (13): 2636-42 PMID28900501show ga Vincristine is extensively used chemotherapeutic medicine to treat leukemia. However, it remains a critical clinical problem with regard to its toxicity and drug-resistance. AMP-activated protein kinase (AMPK) is an energy sensor that is pivotal in maintaining cell metabolic homeostasis. It is reported that AMPK is involved in vincristine-induced apoptosis. However, whether AMPK is involved in chemotherapy-resistance is largely unclear. It is well-documented that metformin, a widely used medicine to treat type II diabetes, possesses anti-cancer activities, yet whether metformin affects leukemia cell viability via vincristine is unknown. In this study, we showed that both AMPK?1 mRNA and phosphorylated AMPK protein levels were significantly decreased in clinical leukemia samples. We further demonstrated that metformin sensitized leukemia cells to vincristine-induced apoptosis in an AMPK-dependent manner. In addition, knockdown of AMPK?1 significantly reduced the effects of metformin on vincristine-induced apoptosis. Taken together, these results indicate that AMPK activation is critical in metformin effects on vincristine-induced apoptosis and suggest a putative strategy of a combination therapy using metformin and vincristine in treatment of leukemia. äMetformin Sensitizes Leukemia Cells to Vincristine via Activation of A(epmc).pdf DeepDyve Pubget Overpricing