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10.1038/ncomms3959 http://scihub22266oqcxt.onion/10.1038/ncomms3959 C5594919!5594919!24343363     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2013 ; 4 (ä): 2959 Nephropedia Template TP {{tp|p=24343363|t=2013. Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T cell development |pdf=|usr=}}{{24343363}} gab.com Text Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T cell development JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=24343363 #FOAvip The thoracic thymus is the primary vertebrate organ for T cell generation. Accessory cervical thymi have also been identified in humans and mice, and shown in mice to be independent functional organs that support T cell development. However, their origin and functional significance remain unclear. Here we show that cervical thymi in mice have two origins: delayed differentiation of endodermal precursors, and transdifferentiation of parathyroid-fated cells. Compared to thoracic thymus, parathyroid-origin cervical thymi (pCT) express low levels of the thymic epithelial cell-specific transcription factor FOXN1. Consequently, pCT form a distinct microenvironment that supports an atypical thymocyte development pathway, generating T cells with unconventional phenotypic characteristics. Our data demonstrate a transdifferentiation origin for a subset of cervical thymi, with specific functional consequences for T cell development. Twit Text FOAVip Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T cell development ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=24343363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24343363 #FOAvip English Wikipedia <ref>{{Cite pmid|24343363}}</ref> Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T cell development #MMPMID24343363 Li J; Liu Z; Xiao S; Manley NR Nat Commun 2013[]; 4 (ä): 2959 PMID24343363show ga The thoracic thymus is the primary vertebrate organ for T cell generation. Accessory cervical thymi have also been identified in humans and mice, and shown in mice to be independent functional organs that support T cell development. However, their origin and functional significance remain unclear. Here we show that cervical thymi in mice have two origins: delayed differentiation of endodermal precursors, and transdifferentiation of parathyroid-fated cells. Compared to thoracic thymus, parathyroid-origin cervical thymi (pCT) express low levels of the thymic epithelial cell-specific transcription factor FOXN1. Consequently, pCT form a distinct microenvironment that supports an atypical thymocyte development pathway, generating T cells with unconventional phenotypic characteristics. Our data demonstrate a transdifferentiation origin for a subset of cervical thymi, with specific functional consequences for T cell development. äTransdifferentiation of parathyroid cells into cervical thymi promotes(epmc).pdf DeepDyve Pubget Overpricing