Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s13046-017-0595-0 http://scihub22266oqcxt.onion/10.1186/s13046-017-0595-0 C5594604!5594604 !28893318     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28893318 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28893318 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Clin+Cancer+Res 2017 ; 36 (1 ): 125 Nephropedia Template TP {{tp|p=28893318 |t=2017. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population |pdf=|usr=}}{{28893318 }} gab.com Text ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population JO: J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28893318 #FOAvip BACKGROUND: ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with ?-catenin and inhibits CBP function as a co-activator of Wnt/?-catenin-mediated transcription. Given its ability to inhibit Wnt/?-catenin signaling pathway, ICG-001 has been used in some tumor types to exert its anticarcinogenic effect. Here, we examined ICG-001 and its potential role as a therapeutic in gastric cancer (GC). METHODS: The gastric cancer cell lines SGC-7901, MGC-803, BGC-823 and MKN-45 were used in vitro and in vivo. The abilities of cell proliferation, tumor sphere formation, metastasis, tumorgenesis and chemoresistance to chemotherapy drugs in vitro were evaluated by MTT assay, colony formation assay, flow cytometry, migration and invasion assay, and tumor spheres culture. The in vivo experiments were performed using a subcutaneous transplantation tumor model in athymic nude mice. Alterations at RNA and protein levels were followed by qRT-PCR, western blot, coimmunoprecipitations and immunofluorescence assay. RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of ?-catenin with CBP and N-cadherin, but promoting association of ?-catenin with P300 and E-cadherin, instead of altering the distribution and expression of ?-catenin. CONCLUSIONS: Our findings suggest that ICG-001 suppresses GC cell line growth, metastasis and reduces its stem cell-like properties and chemoresistance, indicating that ICG-001 is a potentially useful small molecule therapeutic for GC. Twit Text FOAVip ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population ????J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28893318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28893318 #FOAvip English Wikipedia <ref>{{Cite pmid|28893318 }}</ref> ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population #MMPMID28893318 Liu Y ; Chen H ; Zheng P ; Zheng Y ; Luo Q ; Xie G ; Ma Y ; Shen L J Exp Clin Cancer Res 2017[Sep]; 36 (1 ): 125 PMID28893318 show ga BACKGROUND: ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with ?-catenin and inhibits CBP function as a co-activator of Wnt/?-catenin-mediated transcription. Given its ability to inhibit Wnt/?-catenin signaling pathway, ICG-001 has been used in some tumor types to exert its anticarcinogenic effect. Here, we examined ICG-001 and its potential role as a therapeutic in gastric cancer (GC). METHODS: The gastric cancer cell lines SGC-7901, MGC-803, BGC-823 and MKN-45 were used in vitro and in vivo. The abilities of cell proliferation, tumor sphere formation, metastasis, tumorgenesis and chemoresistance to chemotherapy drugs in vitro were evaluated by MTT assay, colony formation assay, flow cytometry, migration and invasion assay, and tumor spheres culture. The in vivo experiments were performed using a subcutaneous transplantation tumor model in athymic nude mice. Alterations at RNA and protein levels were followed by qRT-PCR, western blot, coimmunoprecipitations and immunofluorescence assay. RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of ?-catenin with CBP and N-cadherin, but promoting association of ?-catenin with P300 and E-cadherin, instead of altering the distribution and expression of ?-catenin. CONCLUSIONS: Our findings suggest that ICG-001 suppresses GC cell line growth, metastasis and reduces its stem cell-like properties and chemoresistance, indicating that ICG-001 is a potentially useful small molecule therapeutic for GC. |Animals [MESH] |Apoptosis/drug effects [MESH] |Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage [MESH] |Cadherins/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Drug Resistance, Neoplasm/*drug effects [MESH] |E1A-Associated p300 Protein/genetics [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Humans [MESH] |Mice [MESH] |Neoplastic Stem Cells/*drug effects [MESH] |Pyrimidinones/*administration & dosage [MESH] |Stomach Neoplasms/*drug therapy/genetics/pathology [MESH] |Wnt Signaling Pathway [MESH] |Xenograft Model Antitumor Assays [MESH]ICG-001 suppresses growth of gastric cancer cells and reduces chemores(epmc).pdf DeepDyve Pubget Overpricing