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10.4049/jimmunol.1501529 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501529 C5594569!5594569!26582949     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (1): 437-47 Nephropedia Template TP {{tp|p=26582949|t=2016. Caspase-12, but not caspase-11, inhibits obesity and insulin resistance |pdf=|usr=}}{{26582949}} gab.com Text Caspase-12, but not caspase-11, inhibits obesity and insulin resistance JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26582949 #FOAvip Inflammation is well established to significantly impact metabolic diseases. The inflammatory protease caspase-1 has been implicated in metabolic dysfunction, however a potential role for the related inflammatory caspases is currently unknown. In this study, we investigated a role for caspase-11 and caspase-12 in obesity and insulin resistance. Loss of caspase-12 in two independently generated mouse strains predisposed mice to develop obesity, metabolic inflammation and insulin resistance, while loss of caspase-11 had no effect. The use of bone marrow chimeras determined that deletion of caspase-12 in the radio-resistant compartment was responsible for this metabolic phenotype. The Nlrp3 inflammasome pathway mediated the metabolic syndrome of caspase-12-deficient mice as ablation of Nlrp3 reversed Casp12?/? mice obesity phenotype. While the majority of people lack a functional caspase-12 due to a T125 single nucleotide polymorphism (SNP) that introduces a premature stop codon, a fraction of African descendents express full-length caspase-12. Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African-American obese children. However, analysis of the Dallas Heart Study African American cohort indicated that the coding T125C SNP was not associated with metabolic parameters in humans, suggesting that host specific differences mediate the expressivity of metabolic disease. Twit Text FOAVip Caspase-12, but not caspase-11, inhibits obesity and insulin resistance ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26582949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26582949 #FOAvip English Wikipedia <ref>{{Cite pmid|26582949}}</ref> Caspase-12, but not caspase-11, inhibits obesity and insulin resistance #MMPMID26582949 Skeldon AM; Morizot A; Douglas T; Santoro N; Kursawe R; Kozlitina J; Caprio S; Mehal WZ; Saleh M J Immunol 2016[Jan]; 196 (1): 437-47 PMID26582949show ga Inflammation is well established to significantly impact metabolic diseases. The inflammatory protease caspase-1 has been implicated in metabolic dysfunction, however a potential role for the related inflammatory caspases is currently unknown. In this study, we investigated a role for caspase-11 and caspase-12 in obesity and insulin resistance. Loss of caspase-12 in two independently generated mouse strains predisposed mice to develop obesity, metabolic inflammation and insulin resistance, while loss of caspase-11 had no effect. The use of bone marrow chimeras determined that deletion of caspase-12 in the radio-resistant compartment was responsible for this metabolic phenotype. The Nlrp3 inflammasome pathway mediated the metabolic syndrome of caspase-12-deficient mice as ablation of Nlrp3 reversed Casp12?/? mice obesity phenotype. While the majority of people lack a functional caspase-12 due to a T125 single nucleotide polymorphism (SNP) that introduces a premature stop codon, a fraction of African descendents express full-length caspase-12. Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African-American obese children. However, analysis of the Dallas Heart Study African American cohort indicated that the coding T125C SNP was not associated with metabolic parameters in humans, suggesting that host specific differences mediate the expressivity of metabolic disease. äCaspase-12, but not caspase-11, inhibits obesity and insulin resistanc(epmc).pdf DeepDyve Pubget Overpricing