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2017 ; 14
(1
): 46
Nephropedia Template TP
gab.com Text
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English Wikipedia
Preventing HIV infection without targeting the virus: how reducing HIV target
cells at the genital tract is a new approach to HIV prevention
#MMPMID28893304
Lajoie J
; Mwangi L
; Fowke KR
AIDS Res Ther
2017[Sep]; 14
(1
): 46
PMID28893304
show ga
For over three decades, HIV infection has had a tremendous impact on the lives of
individuals and public health. Microbicides and vaccines studies have shown that
immune activation at the genital tract is a risk factor for HIV infection.
Furthermore, lower level of immune activation, or what we call immune quiescence,
has been associated with a lower risk of HIV acquisition. This unique phenotype
is observed in highly-exposed seronegative individuals from different populations
including female sex workers from the Pumwani cohort in Nairobi, Kenya. Here, we
review the link between immune activation and susceptibility to HIV infection. We
also describe a new concept in prevention where, instead of targeting the virus,
we modulate the host immune system to resist HIV infection. Mimicking the immune
quiescence phenotype might become a new strategy in the toolbox of biomedical
methods to prevent HIV infection. Clinical trial registration on
clinicaltrial.gov: #NCT02079077.
|Aspirin/administration & dosage/therapeutic use
[MESH]