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2017 ; 9
(8
): 2692-2696
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How to design a randomized clinical trial: tips and tricks for conduct a
successful study in thoracic disease domain
#MMPMID28932577
Guerrera F
; Renaud S
; Tabbò F
; Filosso PL
J Thorac Dis
2017[Aug]; 9
(8
): 2692-2696
PMID28932577
show ga
Randomized controlled trials (RCTs) are considered one of the highest level of
evidence in clinical practice, due to their strong confidence and robustness in
producing data. The "randomization" (e.g., allocating patients randomly in each
group of the study) allows eliminating many pre-analytical differences that might
bias the entire study. Nevertheless, RCTs aren't free of internal pitfalls that
might make them not easy to be developed or utilized. Our objective is to explain
RCT management difficulties and suggest certain tips useful for the design of a
RCT in thoracic disease domain. In particular have a realistic timeline, define a
clear objective and precise endpoints, balance the study with a correct
randomization and focus on the right equilibrium between strict selection
criteria and more heterogeneous parameters are key elements that help researchers
assuring a strong scientific validity.