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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Radiol+Rep 2017 ; 5 (11): ä Nephropedia Template TP
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Imaging Features of Toxicities by Immune Checkpoint Inhibitors in Cancer Therapy #MMPMID28959504
Widmann G; Nguyen VA; Plaickner J; Jaschke W
Curr Radiol Rep 2017[]; 5 (11): ä PMID28959504show ga
Purpose of review: With the increasing use of immune checkpoint inhibitors in cancer therapy radiographic profiling of frequent and serious immune-related adverse events (irAEs) becomes more relevant. This article reviews imaging features of irAEs induced by the anti-CTLA-4 and anti-PD-1 antibodies ipilimumab, nivolumab and pembrolizumab. Recent findings: Important radiological manifestations are immune-related colitis, hepatitis, pancreatitis, hypophysitis, pneumonitis, arthritis and sarcoid-like lymphadenopathy. Typical imaging features are summarized and compared with other relevant differential diagnoses. Summary: Early diagnosis and appropriate therapeutic decisions are required for a successful treatment of irAEs. In addition to staging and follow-up imaging, identification and monitoring of adverse events becomes an important radiologic aspect in oncologic care.