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10.1038/s41598-017-11627-w http://scihub22266oqcxt.onion/10.1038/s41598-017-11627-w C5593964!5593964!28894234     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28894234|t=2017. Elevated UMOD methylation level in peripheral blood is associated with gout risk |pdf=|usr=}}{{28894234}} gab.com Text Elevated UMOD methylation level in peripheral blood is associated with gout risk JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894234 #FOAvip Uromodulin (UMOD) encodes an uromodulin glycoprotein, and its mutation results in uromodulin glycoprotein dysfunction and the occurrence of gout. The aim of our study was to assess whether UMOD methylation could predict the risk of gout. A total of 89 sporadic gout cases and 103 age and gender-matched healthy controls were recruited in this study. UMOD methylation level was determined by quantitative methylation-specific PCR (qMSP) in peripheral blood, and the percentage of methylated reference (PMR) was described to represent the methylation level. Our results showed that UMOD methylation was significantly higher in gout cases than controls (median: 1.45 versus 0.75, P?<?0.001). The area under curve (AUC) of UMOD methylation in gout was 0.764 (P?=?2.90E-10) with a sensitivity of 65.2% and a specificity of 88.3%. UMOD methylation level was shown to be significantly correlated with the serum level of uric acid (UA) (r?=??0.208, P?=?0.035). Besides, the luciferase reporter assay showed that UMOD CpG island region was able to upregulate gene expression (fold change?=?2, P?=?0.004). In conclusion, UMOD methylation assessment might be used to predict the occurrence of gout. Twit Text FOAVip Elevated UMOD methylation level in peripheral blood is associated with gout risk ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894234 #FOAvip English Wikipedia <ref>{{Cite pmid|28894234}}</ref> Elevated UMOD methylation level in peripheral blood is associated with gout risk #MMPMID28894234 Yang Y; Chen X; Hu H; Jiang Y; Yu H; Dai J; Mao Y; Duan S Sci Rep 2017[]; 7 (ä): ä PMID28894234show ga Uromodulin (UMOD) encodes an uromodulin glycoprotein, and its mutation results in uromodulin glycoprotein dysfunction and the occurrence of gout. The aim of our study was to assess whether UMOD methylation could predict the risk of gout. A total of 89 sporadic gout cases and 103 age and gender-matched healthy controls were recruited in this study. UMOD methylation level was determined by quantitative methylation-specific PCR (qMSP) in peripheral blood, and the percentage of methylated reference (PMR) was described to represent the methylation level. Our results showed that UMOD methylation was significantly higher in gout cases than controls (median: 1.45 versus 0.75, P? äElevated UMOD methylation level in peripheral blood is associated with(epmc).pdf DeepDyve Pubget Overpricing