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10.1038/s41598-017-11582-6 http://scihub22266oqcxt.onion/10.1038/s41598-017-11582-6 C5593963!5593963 !28894214     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28894214 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice |pdf=|usr=}}{{28894214 }} gab.com Text The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894214 #FOAvip Diabetic nephropathy is still a common complication of type 2 diabetes mellitus (T2DM) and improvement of endothelial dysfunction (ED) and inhibition of reactive oxygen species (ROS) are considered important targets for new therapies. Recently, we developed a new class of compounds (Sul compounds) which inhibit mitochondrial ROS production. Here, we tested the therapeutic effects of Sul-121 on ED and kidney damage in experimental T2DM. Diabetic db/db and lean mice were implanted with osmotic pumps delivering Sul-121 (2.2?mg/kg/day) or vehicle from age 10 to 18 weeks. Albuminuria, blood pressure, endothelial mediated relaxation, renal histology, plasma creatinine, and H(2)O(2) levels were assessed. Sul-121 prevented progression of albuminuria and attenuated kidney damage in db/db, as evidenced by lower glomerular fibronectin expression (~50%), decreased focal glomerular sclerosis score (~40%) and normalization of glomerular size and kidney weight. Further, Sul-121 restored endothelium mediated vasorelaxation through increased production of Nitric Oxide production and normalized plasma H(2)O(2) levels. Sul-121 treatment in lean mice demonstrated no observable major side-effects, indicating that Sul-121 is well tolerated. Our data show that Sul-121 inhibits progression of diabetic kidney damage via a mechanism that involves restoration of endothelial function and attenuation of oxidative stress. Twit Text FOAVip The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894214 #FOAvip English Wikipedia <ref>{{Cite pmid|28894214 }}</ref> The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice #MMPMID28894214 Lambooy SPH ; Bidadkosh A ; Nakladal D ; van Buiten A ; Girgis RAT ; van der Graaf AC ; Wiedenmann TJ ; Koster RA ; Vogelaar P ; Buikema H ; Henning RH ; Deelman LE Sci Rep 2017[Sep]; 7 (1 ): 11165 PMID28894214 show ga Diabetic nephropathy is still a common complication of type 2 diabetes mellitus (T2DM) and improvement of endothelial dysfunction (ED) and inhibition of reactive oxygen species (ROS) are considered important targets for new therapies. Recently, we developed a new class of compounds (Sul compounds) which inhibit mitochondrial ROS production. Here, we tested the therapeutic effects of Sul-121 on ED and kidney damage in experimental T2DM. Diabetic db/db and lean mice were implanted with osmotic pumps delivering Sul-121 (2.2?mg/kg/day) or vehicle from age 10 to 18 weeks. Albuminuria, blood pressure, endothelial mediated relaxation, renal histology, plasma creatinine, and H(2)O(2) levels were assessed. Sul-121 prevented progression of albuminuria and attenuated kidney damage in db/db, as evidenced by lower glomerular fibronectin expression (~50%), decreased focal glomerular sclerosis score (~40%) and normalization of glomerular size and kidney weight. Further, Sul-121 restored endothelium mediated vasorelaxation through increased production of Nitric Oxide production and normalized plasma H(2)O(2) levels. Sul-121 treatment in lean mice demonstrated no observable major side-effects, indicating that Sul-121 is well tolerated. Our data show that Sul-121 inhibits progression of diabetic kidney damage via a mechanism that involves restoration of endothelial function and attenuation of oxidative stress. |Albuminuria/prevention & control [MESH] |Animals [MESH] |Antioxidants/*administration & dosage [MESH] |Chromans/*administration & dosage [MESH] |Diabetes Mellitus, Experimental/*complications [MESH] |Diabetic Nephropathies/*drug therapy/*prevention & control [MESH] |Endothelium/*physiology [MESH] |Histocytochemistry [MESH] |Hydrogen Peroxide/analysis [MESH] |Kidney Function Tests [MESH] |Kidney/*pathology [MESH] |Mice [MESH] |Piperazines/*administration & dosage [MESH]The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits(epmc).pdf DeepDyve Pubget Overpricing