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10.1038/s41467-017-00531-6 http://scihub22266oqcxt.onion/10.1038/s41467-017-00531-6 C5593929!5593929!28894149     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28894149|t=2017. A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity |pdf=|usr=}}{{28894149}} gab.com Text A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28894149 #FOAvip Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific intestinal T-cell populations, and secretory IgA expression. A PAT-perturbed microbial community is necessary for host effects and sufficient to transfer delayed secretory IgA expression. Additionally, early-life antibiotic exposure has lasting and transferable effects on microbial community network topology. Our results indicate that a single early-life macrolide course can alter the microbiota and modulate host immune phenotypes that persist long after exposure has ceased. Twit Text FOAVip A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28894149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894149 #FOAvip English Wikipedia <ref>{{Cite pmid|28894149}}</ref> A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity #MMPMID28894149 Ruiz VE; Battaglia T; Kurtz ZD; Bijnens L; Ou A; Engstrand I; Zheng X; Iizumi T; Mullins BJ; Müller CL; Cadwell K; Bonneau R; Perez-Perez GI; Blaser MJ Nat Commun 2017[]; 8 (ä): ä PMID28894149show ga Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific intestinal T-cell populations, and secretory IgA expression. A PAT-perturbed microbial community is necessary for host effects and sufficient to transfer delayed secretory IgA expression. Additionally, early-life antibiotic exposure has lasting and transferable effects on microbial community network topology. Our results indicate that a single early-life macrolide course can alter the microbiota and modulate host immune phenotypes that persist long after exposure has ceased. äA single early-in-life macrolide course has lasting effects on murine (epmc).pdf DeepDyve Pubget Overpricing