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10.1038/s41598-017-09689-x http://scihub22266oqcxt.onion/10.1038/s41598-017-09689-x C5593840!5593840 !28894116     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28894116 &cmd=llinks): Failed to open stream: HTTP request failed! 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Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy |pdf=|usr=}}{{28894116 }} gab.com Text Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894116 #FOAvip The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported. We immunophenotyped tonsillar IL10-expressing B cells (B10) and observed IL10 production in activated B cells at every developmental stage. Finally, we identified a relationship between decreased B10 percentages, increased proportion of the germinal centre (GC) population and hypertrophied tonsils (HT). Our findings provide greater insight into the role of B10 in GC reactions and characterized their involvement in the pathogenesis of tonsillar dysfunction. Twit Text FOAVip Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894116 #FOAvip English Wikipedia <ref>{{Cite pmid|28894116 }}</ref> Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy #MMPMID28894116 Sarmiento Varon L ; De Rosa J ; Machicote A ; Billordo LA ; Baz P ; Fernández PM ; Kaimen Maciel I ; Blanco A ; Arana EI Sci Rep 2017[Sep]; 7 (1 ): 11077 PMID28894116 show ga The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported. We immunophenotyped tonsillar IL10-expressing B cells (B10) and observed IL10 production in activated B cells at every developmental stage. Finally, we identified a relationship between decreased B10 percentages, increased proportion of the germinal centre (GC) population and hypertrophied tonsils (HT). Our findings provide greater insight into the role of B10 in GC reactions and characterized their involvement in the pathogenesis of tonsillar dysfunction. |B-Lymphocytes/*immunology/*metabolism [MESH] |Biomarkers [MESH] |Computational Biology/methods [MESH] |Germinal Center/immunology [MESH] |Humans [MESH] |Hypertrophy [MESH] |Immunophenotyping [MESH] |Interleukin-10/*biosynthesis [MESH] |Palatine Tonsil/*cytology/*immunology/metabolism [MESH]Characterization of tonsillar IL10 secreting B cells and their role in(epmc).pdf DeepDyve Pubget Overpricing