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10.1038/s41598-017-11703-1 http://scihub22266oqcxt.onion/10.1038/s41598-017-11703-1 C5593833!5593833 !28894272     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28894272 &cmd=llinks): Failed to open stream: HTTP request failed! 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T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model |pdf=|usr=}}{{28894272 }} gab.com Text T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894272 #FOAvip The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to the parasite load. We demonstrated that local cellular immunity and fibrogenesis are actually protective and fully able to limit metacestode growth in the liver of low or medium dose-infected mice (LDG or MDG), or even to clear it, while impairment of cellular immunity is followed by a more rapid and severe course of the disease in high dose-infected mice (HDG). And recruitment and/ or proliferation of memory T cells (including CD4 Tem, CD8 Tcm and CD8 Tem) and imbalance of T1/T2/T17/Treg-type T cells in liver were not only associated with clearance of the parasite infection in LDG, but also with increased hepatic injury in HDG; in particular the dual role of CD8 T cells depending on the parasite load and the various stages of metacestode growth. Besides, we first demonstrate the association between LAG3- or 2B4-expressing T cells exhaustion and HD inocula in late stages. Our quantitative experimental model appears fully appropriate to study immunomodulation as a therapeutic strategy for patients with Alveolar Echinococcosis. Twit Text FOAVip T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28894272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894272 #FOAvip English Wikipedia <ref>{{Cite pmid|28894272 }}</ref> T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model #MMPMID28894272 Zhang C ; Shao Y ; Yang S ; Bi X ; Li L ; Wang H ; Yang N ; Li Z ; Sun C ; Li L ; Lü G ; Aji T ; Vuitton DA ; Lin R ; Wen H Sci Rep 2017[Sep]; 7 (1 ): 11153 PMID28894272 show ga The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to the parasite load. We demonstrated that local cellular immunity and fibrogenesis are actually protective and fully able to limit metacestode growth in the liver of low or medium dose-infected mice (LDG or MDG), or even to clear it, while impairment of cellular immunity is followed by a more rapid and severe course of the disease in high dose-infected mice (HDG). And recruitment and/ or proliferation of memory T cells (including CD4 Tem, CD8 Tcm and CD8 Tem) and imbalance of T1/T2/T17/Treg-type T cells in liver were not only associated with clearance of the parasite infection in LDG, but also with increased hepatic injury in HDG; in particular the dual role of CD8 T cells depending on the parasite load and the various stages of metacestode growth. Besides, we first demonstrate the association between LAG3- or 2B4-expressing T cells exhaustion and HD inocula in late stages. Our quantitative experimental model appears fully appropriate to study immunomodulation as a therapeutic strategy for patients with Alveolar Echinococcosis. |*Immune Tolerance [MESH] |Animals [MESH] |Antigens, Protozoan/immunology [MESH] |Cytokines/metabolism [MESH] |Disease Models, Animal [MESH] |Echinococcosis, Hepatic/*immunology/*parasitology/pathology [MESH] |Echinococcus multilocularis/*immunology [MESH] |Female [MESH] |Humans [MESH] |Immunity, Cellular [MESH] |Liver Cirrhosis [MESH] |Lymphocyte Subsets/immunology/metabolism [MESH] |Mice [MESH] |Phenotype [MESH]T-cell tolerance and exhaustion in the clearance of Echinococcus multi(epmc).pdf DeepDyve Pubget Overpricing