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10.18632/oncotarget.18628 http://scihub22266oqcxt.onion/10.18632/oncotarget.18628 C5593690!5593690!28915718     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (34): 57870-81 Nephropedia Template TP {{tp|p=28915718|t=2017. The PI3K/Akt pathway: a critical player in intervertebral disc degeneration |pdf=|usr=}}{{28915718}} gab.com Text The PI3K/Akt pathway: a critical player in intervertebral disc degeneration JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915718 #FOAvip Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment. In the current review, we summarize recent progression on activation and negative regulation of the PI3K/Akt signaling pathway, and highlight its impact on IDD. Targeting this pathway could become an attractive therapeutic strategy for IDD in the near future. Twit Text FOAVip The PI3K/Akt pathway: a critical player in intervertebral disc degeneration ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28915718 #FOAvip English Wikipedia <ref>{{Cite pmid|28915718}}</ref> The PI3K/Akt pathway: a critical player in intervertebral disc degeneration #MMPMID28915718 Ouyang ZH; Wang WJ; Yan YG; Wang B; Lv GH Oncotarget 2017[Aug]; 8 (34): 57870-81 PMID28915718show ga Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment. In the current review, we summarize recent progression on activation and negative regulation of the PI3K/Akt signaling pathway, and highlight its impact on IDD. Targeting this pathway could become an attractive therapeutic strategy for IDD in the near future. äThe PI3K/Akt pathway: a critical player in intervertebral disc degener(epmc).pdf DeepDyve Pubget Overpricing