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2017 ; 8
(34
): 57327-57336
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Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis
and systematic review
#MMPMID28915673
Wang R
; Zhang Y
; Lin X
; Gao Y
; Zhu Y
Oncotarget
2017[Aug]; 8
(34
): 57327-57336
PMID28915673
show ga
CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that
is encoded by NT5E gene, plays multiple roles in tumor processes. Previous
studies have presented a potential value of CD73 served as a detectable biomarker
for prognosis of several solid tumors, but the results were more controversially.
A comprehensive meta-analysis was conducted to precisely evaluate the prognostic
role of CD73 in solid tumors. The included studies were searched in PubMed, Web
of Science and EBSCO from Jan 1990 to Jan 2016. Pooled hazard ratios (HR) and
corresponding 95% confidence intervals (CI) for overall survival (OS), disease
free survival (DFS) were carried out using a fixed or random effects model.
Totally, 13 studies about 12,533 patients were included. CD73-high expression was
correlating with poor OS (pooled HR = 1.28, 95% CI = 1.19-1.37). In addition,
CD73 expression had borderline association with worse DFS (pooled HR = 1.28, 95%
CI = 1.01-1.62). Egger's tests indicated that there was no evidence of
significant publication bias. CD73 is an efficient prognostic biomarker in solid
tumors, and over-expression of CD73 is associated with inverse OS or DFS. But
this predictive value and target therapy for clinical practice yet needs advanced
research.