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2017 ; 8
(34
): 57099-57108
Nephropedia Template TP
gab.com Text
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The prevalence, subtypes and associated factors of hyperuricemia in lupus
nephritis patients at chronic kidney disease stages 1-3
#MMPMID28915657
Liu S
; Gong Y
; Ren H
; Zhang W
; Chen X
; Zhou T
; Li X
; Chen N
Oncotarget
2017[Aug]; 8
(34
): 57099-57108
PMID28915657
show ga
There is a high prevalence of hyperuricemia (HUA) in the chronic kidney disease
(CKD) population. However, there's a dearth of research on HUA's prevalence,
subtypes, early detection, and treatment strategies of HUA in lupus nephritis
(LN) patients. The aim of this study is to address these knowledge gaps. LN
patients presenting to the Department of Nephrology at Shanghai Rui Jin Hospital
from January 2011 to January 2016 were recruited. The effective sample size was
derived using the power analysis. The demographic, clinical and laboratory
characteristics of the LN patients with HUA were compared with those of patients
without HUA. Two statistical models for analyzing HUA were built and compared
using the receiver operating characteristic (ROC) curve analysis. The total
prevalence of HUA in the cohort was 40.11%. The subtypes of HUA included urate
underexcretion-type, overproduction-type and combined-type, which proportion
being 67.7%, 9.7% and 22.6% respectively. The CKD stage was closely associated
with the prevalence of HUA in patients with LN. The other significant associated
factors were hypertension, triglycerides, serum creatinine, serum albumin,
hemoglobin, parathyroid hormone, phosphorus, calcium, etc. The statistical
algorithm successfully identified LN patients at risk of HUA. In conclusion,
there was a high prevalence of HUA in LN patients at CKD stages 1-3, and renal
underexcretion hyperuricemia was the most prevalent subtype. The occurrence of
HUA in LN may be related to renal insufficiency, metabolic disorder and lupus
itself. Early care coordination programs can employ risk models to improve HUA
prevention and target interventions in LN patients.