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10.18632/oncotarget.16992 http://scihub22266oqcxt.onion/10.18632/oncotarget.16992 C5593574!5593574!28915603     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (34): 56443-59 Nephropedia Template TP {{tp|p=28915603|t=2017. Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer |pdf=|usr=}}{{28915603}} gab.com Text Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915603 #FOAvip In non?small cell lung cancer (NSCLC), estrogen significantly promotes NSCLC cell growth via estrogen receptor beta (ER?). However, the effects by which ER? contributes to metastasis in NSCLC have not been previously reported. This study aims at defining whether the stimulation of ER? promotes NSCLC metastasis in vitro and in vivo. Here, Our results showed that estrogen and ER? agonist enhanced aggressiveness of two lung cancer cell lines (A549 and H1793) and promoted murine lung metastasis formation. ER-inhibitor Fulvestrant treatment or ER?-knockdown significantly suppressed the migration, invasion and nodule formation of NSCLC cells. The expression level of ER? protein was analyzed in matched samples of metastatic lymph node and primary tumor tissues from the same individuals, and we found significantly higher levels of ER? were expressed in lymph node compared to primary tumor tissues. Moreover, Studies on both surgical biopsies and on lung cancer cells revealed that the expression level of ER? and matrix-metalloproteinase-2 (MMP-2) were associated. Furthermore, inhibition of ER? resulted in down-regulation of MMP-2 expression. Taken together, our results demonstrate that activation of ER? in lung cancer cells promotes tumor metastasis through increasing expression of invasiveness-associated MMP-2. These results also highlight the therapeutic potential of inhibition of ER?in the treatment of advanced NSCLC. Twit Text FOAVip Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28915603 #FOAvip English Wikipedia <ref>{{Cite pmid|28915603}}</ref> Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer #MMPMID28915603 Fan S; Liao Y; Liu C; Huang Q; Liang H; Ai B; Fu S; Zhou S Oncotarget 2017[Aug]; 8 (34): 56443-59 PMID28915603show ga In non?small cell lung cancer (NSCLC), estrogen significantly promotes NSCLC cell growth via estrogen receptor beta (ER?). However, the effects by which ER? contributes to metastasis in NSCLC have not been previously reported. This study aims at defining whether the stimulation of ER? promotes NSCLC metastasis in vitro and in vivo. Here, Our results showed that estrogen and ER? agonist enhanced aggressiveness of two lung cancer cell lines (A549 and H1793) and promoted murine lung metastasis formation. ER-inhibitor Fulvestrant treatment or ER?-knockdown significantly suppressed the migration, invasion and nodule formation of NSCLC cells. The expression level of ER? protein was analyzed in matched samples of metastatic lymph node and primary tumor tissues from the same individuals, and we found significantly higher levels of ER? were expressed in lymph node compared to primary tumor tissues. Moreover, Studies on both surgical biopsies and on lung cancer cells revealed that the expression level of ER? and matrix-metalloproteinase-2 (MMP-2) were associated. Furthermore, inhibition of ER? resulted in down-regulation of MMP-2 expression. Taken together, our results demonstrate that activation of ER? in lung cancer cells promotes tumor metastasis through increasing expression of invasiveness-associated MMP-2. These results also highlight the therapeutic potential of inhibition of ER?in the treatment of advanced NSCLC. äEstrogen promotes tumor metastasis via estrogen receptor beta-mediated(epmc).pdf DeepDyve Pubget Overpricing