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10.18632/oncotarget.18473 http://scihub22266oqcxt.onion/10.18632/oncotarget.18473 C5593534!5593534 !28915563     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28915563 &cmd=llinks): Failed to open stream: HTTP request failed! 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NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia |pdf=|usr=}}{{28915563 }} gab.com Text NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915563 #FOAvip NiaoDuQing (NDQ) granules, a traditional Chinese medicine, has been clinically used in China for over fourteen years to treat chronic kidney disease (CKD). To elucidate the mechanisms underlying the therapeutic benefits of NDQ, we designed an approach incorporating chemoinformatics, bioinformatics, network biology methods, and cellular and molecular biology experiments. A total of 182 active compounds were identified in NDQ granules, and 397 putative targets associated with different diseases were derived through ADME modelling and target prediction tools. Protein-protein interaction networks of CKD-related and putative NDQ targets were constructed, and 219 candidate targets were identified based on topological features. Pathway enrichment analysis showed that the candidate targets were mostly related to the TGF-?, the p38MAPK, and the erythropoietin (EPO) receptor signaling pathways, which are known contributors to renal fibrosis and/or renal anemia. A rat model of CKD was established to validate the drug-target mechanisms predicted by the systems pharmacology analysis. Experimental results confirmed that NDQ granules exerted therapeutic effects on CKD and its comorbidities, including renal anemia, mainly by modulating the TGF-? and EPO signaling pathways. Thus, the pharmacological actions of NDQ on CKD symptoms correlated well with in silico predictions. Twit Text FOAVip NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28915563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28915563 #FOAvip English Wikipedia <ref>{{Cite pmid|28915563 }}</ref> NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia #MMPMID28915563 Wang X ; Yu S ; Jia Q ; Chen L ; Zhong J ; Pan Y ; Shen P ; Shen Y ; Wang S ; Wei Z ; Cao Y ; Lu Y Oncotarget 2017[Aug]; 8 (34 ): 55920-55937 PMID28915563 show ga NiaoDuQing (NDQ) granules, a traditional Chinese medicine, has been clinically used in China for over fourteen years to treat chronic kidney disease (CKD). To elucidate the mechanisms underlying the therapeutic benefits of NDQ, we designed an approach incorporating chemoinformatics, bioinformatics, network biology methods, and cellular and molecular biology experiments. A total of 182 active compounds were identified in NDQ granules, and 397 putative targets associated with different diseases were derived through ADME modelling and target prediction tools. Protein-protein interaction networks of CKD-related and putative NDQ targets were constructed, and 219 candidate targets were identified based on topological features. Pathway enrichment analysis showed that the candidate targets were mostly related to the TGF-?, the p38MAPK, and the erythropoietin (EPO) receptor signaling pathways, which are known contributors to renal fibrosis and/or renal anemia. A rat model of CKD was established to validate the drug-target mechanisms predicted by the systems pharmacology analysis. Experimental results confirmed that NDQ granules exerted therapeutic effects on CKD and its comorbidities, including renal anemia, mainly by modulating the TGF-? and EPO signaling pathways. Thus, the pharmacological actions of NDQ on CKD symptoms correlated well with in silico predictions. äNiaoDuQing granules relieve chronic kidney disease symptoms by decreas(epmc).pdf DeepDyve Pubget Overpricing