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2017 ; 40
(4
): 965-971
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Kidins220 and tumour development: Insights into a complexity of cross-talk among
signalling pathways (Review)
#MMPMID28849114
Cai S
; Cai J
; Jiang WG
; Ye L
Int J Mol Med
2017[Oct]; 40
(4
): 965-971
PMID28849114
show ga
The mechanistic complexes of kinase D-interacting substrate of 220 kDa/ankyrin
repeat-rich membrane spanning (Kidins220/ARMS) bind and integrate a variety of
cellular cues to mediate neuronal activities such as neuronal differentiation,
survival, and cytoskeleton remodelling by interacting with a variety of binding
partners. Accumulated evidence has also indicated its role in the regulation of
vascular development. Mice with Kidins220 knockdown phenotypically present with
cardiovascular abnormalities. Kidins220 also contributes to immunomodulation in
combination with B cells and T cells. Moreover, emerging evidence has revealed
that this protein regulates many crucial cellular processes and thus has been
implicated in an increasing number of malignancies. Here, we review recent
advances in our understanding of Kidins220 and its role in cancer development.
Further investigation is warranted to shed light on the role played by Kidins220
in the dynamic arrangement of the cytoskeleton and epithelial-mesenchymal
transition, and its implication in tumourigenesis and cancer progression.