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10.3892/ijmm.2017.3116 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.3116 C5593456!5593456!28902356     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2017 ; 40 (4): 1047-56 Nephropedia Template TP {{tp|p=28902356|t=2017. miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/?-catenin pathway in cervical cancer |pdf=|usr=}}{{28902356}} gab.com Text miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/ -catenin pathway in cervical cancer JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28902356 #FOAvip Upregulation or downregulation of microRNAs (miRNAs) has been identified in human cervical cancer (CC). However, the character and function of miR-378 in CC remains unknown. In the present study, the authors demonstrated that miR-378 was upregulated in CC used the reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay, and promoted cell proliferation by accelerating the progress of cell cycle and repressing cell apoptosis in CC cells. The predicted target genes of miR-378 were determined by enhanced green fluorescent protein (EGFP) reporter assays, RT-qPCR assay and western blot analysis. miR-378 suppressed the expression of suppression of tumorigenicity 7-like (ST7L) by targeting the 3?-untranslated region (3?-UTR) of ST7L mRNA in HeLa and SiHa cells. ST7L was downregulated in CC using the RT-qPCR assay, and the malignant phenotype of HeLa and SiHa cells were inhibited by ST7L overexpression. In addition, miR-378 activated the Wnt/?-catenin pathway by targeting ST7L in CC cells. In short, miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level in HeLa and SiHa cells, and serves important roles in the malignancy of CC. Twit Text FOAVip miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/ -catenin pathway in cervical cancer ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28902356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28902356 #FOAvip English Wikipedia <ref>{{Cite pmid|28902356}}</ref> miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/?-catenin pathway in cervical cancer #MMPMID28902356 Li S; Yang F; Wang M; Cao W; Yang Z Int J Mol Med 2017[Oct]; 40 (4): 1047-56 PMID28902356show ga Upregulation or downregulation of microRNAs (miRNAs) has been identified in human cervical cancer (CC). However, the character and function of miR-378 in CC remains unknown. In the present study, the authors demonstrated that miR-378 was upregulated in CC used the reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay, and promoted cell proliferation by accelerating the progress of cell cycle and repressing cell apoptosis in CC cells. The predicted target genes of miR-378 were determined by enhanced green fluorescent protein (EGFP) reporter assays, RT-qPCR assay and western blot analysis. miR-378 suppressed the expression of suppression of tumorigenicity 7-like (ST7L) by targeting the 3?-untranslated region (3?-UTR) of ST7L mRNA in HeLa and SiHa cells. ST7L was downregulated in CC using the RT-qPCR assay, and the malignant phenotype of HeLa and SiHa cells were inhibited by ST7L overexpression. In addition, miR-378 activated the Wnt/?-catenin pathway by targeting ST7L in CC cells. In short, miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level in HeLa and SiHa cells, and serves important roles in the malignancy of CC. ämiR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/?-catenin(epmc).pdf DeepDyve Pubget Overpricing