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10.3892/ijmm.2017.3111 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.3111 C5593452!5593452!28902364     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2017 ; 40 (4): 1037-46 Nephropedia Template TP {{tp|p=28902364|t=2017. Functional roles of C/EBP? and SUMO-modification in lung development |pdf=|usr=}}{{28902364}} gab.com Text Functional roles of C/EBP and SUMO-modification in lung development JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28902364 #FOAvip CCAAT enhancer binding protein alpha (C/EBP?) is a transcription factor regulating the core aspects of cell growth and differentiation. The present study investigated the level and functional role of C/EBP? during the development of the rat lung. C/EBP? protein exhibits a dynamic expression pattern. The correlation between the expression of C/EBP? protein and the content of glycogen during lung maturation was analyzed to understand the function of C/EBP? in lung differentiation. The high expression of C/EBP? coincides with the reduction of glycogen in the fetal lung. In addition, the authors identified that changes in the level of C/EBP? are associated with the secretion of pulmonary surfactant. C/EBP? is modified by small ubiquitin-related modifier (SUMO) post-translationally. The results of double immunofluorescence staining and immunoprecipitation demonstrated that SUMO-modified C/EBP? was present in the lung. The sumoylated C/EBP? gradually decreased during lung differentiation and was negatively correlated with pulmonary surfactant secretion, thereby suggesting that the SUMO modification may participate in C/EBP?-mediated lung growth and differentiation. These results indicated that C/EBP? played a role in lung development and provided the insight into the mechanism underlying SUMO-modification. Twit Text FOAVip Functional roles of C/EBP and SUMO-modification in lung development ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28902364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28902364 #FOAvip English Wikipedia <ref>{{Cite pmid|28902364}}</ref> Functional roles of C/EBP? and SUMO-modification in lung development #MMPMID28902364 Chen YD; Liu JY; Lu YM; Zhu HT; Tang W; Wang QX; Lu HY Int J Mol Med 2017[Oct]; 40 (4): 1037-46 PMID28902364show ga CCAAT enhancer binding protein alpha (C/EBP?) is a transcription factor regulating the core aspects of cell growth and differentiation. The present study investigated the level and functional role of C/EBP? during the development of the rat lung. C/EBP? protein exhibits a dynamic expression pattern. The correlation between the expression of C/EBP? protein and the content of glycogen during lung maturation was analyzed to understand the function of C/EBP? in lung differentiation. The high expression of C/EBP? coincides with the reduction of glycogen in the fetal lung. In addition, the authors identified that changes in the level of C/EBP? are associated with the secretion of pulmonary surfactant. C/EBP? is modified by small ubiquitin-related modifier (SUMO) post-translationally. The results of double immunofluorescence staining and immunoprecipitation demonstrated that SUMO-modified C/EBP? was present in the lung. The sumoylated C/EBP? gradually decreased during lung differentiation and was negatively correlated with pulmonary surfactant secretion, thereby suggesting that the SUMO modification may participate in C/EBP?-mediated lung growth and differentiation. These results indicated that C/EBP? played a role in lung development and provided the insight into the mechanism underlying SUMO-modification. äFunctional roles of C/EBP? and SUMO-modification in lung development (epmc).pdf DeepDyve Pubget Overpricing