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10.3892/ijmm.2017.3113 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.3113 C5593451!5593451 !28902342     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28902342 &cmd=llinks): Failed to open stream: HTTP request failed! 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Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma |pdf=|usr=}}{{28902342 }} gab.com Text Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28902342 #FOAvip Osthole is a natural coumarin isolated from Umbelliferae plant monomers. Previous research has indicated that osthole exerts a wide variety of biological effects, acting as anti-seizure, anti-osteoporosis and anti-inflammation. However, the regulatory effect and related molecular mechanism of osthole in intrahepatic cholangiocarcinoma (ICC) remain unknown. In the present study, the authors found that osthole inhibited ICC cell lines in a dose- and time-dependent manner. Osthole also significantly induced mitochondrial-dependent apoptosis by upregulating Bax, cleaved caspase-3, cleaved caspase-9, and cleaved poly ADP-ribose polymerase expression, and by downregulating Bcl-2 expression. Moreover, the levels of p-Akt and PI3K were significantly decreased, while total Akt protein levels were unchanged. Following transfection with wild-type-Akt and constitutively active (CA)-Akt plasmids, the effects of osthole were decreased. Osthole was also able to suppress tumor growth in vivo. Together, these data demonstrated that osthole induces mitochondrial-dependent apoptosis via the PI3K/Akt pathway, suggesting that osthole may represent a novel and effective agent for the treatment of ICC. Twit Text FOAVip Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28902342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28902342 #FOAvip English Wikipedia <ref>{{Cite pmid|28902342 }}</ref> Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma #MMPMID28902342 Zhu X ; Song X ; Xie K ; Zhang X ; He W ; Liu F Int J Mol Med 2017[Oct]; 40 (4 ): 1143-1151 PMID28902342 show ga Osthole is a natural coumarin isolated from Umbelliferae plant monomers. Previous research has indicated that osthole exerts a wide variety of biological effects, acting as anti-seizure, anti-osteoporosis and anti-inflammation. However, the regulatory effect and related molecular mechanism of osthole in intrahepatic cholangiocarcinoma (ICC) remain unknown. In the present study, the authors found that osthole inhibited ICC cell lines in a dose- and time-dependent manner. Osthole also significantly induced mitochondrial-dependent apoptosis by upregulating Bax, cleaved caspase-3, cleaved caspase-9, and cleaved poly ADP-ribose polymerase expression, and by downregulating Bcl-2 expression. Moreover, the levels of p-Akt and PI3K were significantly decreased, while total Akt protein levels were unchanged. Following transfection with wild-type-Akt and constitutively active (CA)-Akt plasmids, the effects of osthole were decreased. Osthole was also able to suppress tumor growth in vivo. Together, these data demonstrated that osthole induces mitochondrial-dependent apoptosis via the PI3K/Akt pathway, suggesting that osthole may represent a novel and effective agent for the treatment of ICC. |Animals [MESH] |Apoptosis/*drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Cholangiocarcinoma/*enzymology/*pathology [MESH] |Coumarins/*pharmacology [MESH] |Male [MESH] |Membrane Potential, Mitochondrial/drug effects [MESH] |Mice, Nude [MESH] |Mitochondria/drug effects/metabolism [MESH] |Phosphatidylinositol 3-Kinases/*metabolism [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH]Osthole induces apoptosis and suppresses proliferation via the PI3K/Ak(epmc).pdf DeepDyve Pubget Overpricing