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10.1183/13993003.02367-2016 http://scihub22266oqcxt.onion/10.1183/13993003.02367-2016 C5593348!5593348 !28775044     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28775044 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+Respir+J 2017 ; 50 (2 ): ä Nephropedia Template TP {{tp|p=28775044 |t=2017. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo |pdf=|usr=}}{{28775044 }} gab.com Text Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo JO: Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=28775044 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases with age, and ageing-related mechanisms such as cellular senescence have been proposed as pathogenic drivers. The lung alveolar epithelium represents a major site of tissue injury in IPF and senescence of this cell population is probably detrimental to lung repair. However, the potential pathomechanisms of alveolar epithelial cell senescence and the impact of senolytic drugs on senescent lung cells and fibrosis remain unknown. Here we demonstrate that lung epithelial cells exhibit increased P16 and P21 expression as well as senescence-associated ?-galactosidase activity in experimental and human lung fibrosis tissue and primary cells.Primary fibrotic mouse alveolar epithelial type (AT)II cells secreted increased amounts of senescence-associated secretory phenotype (SASP) factors in vitro, as analysed using quantitative PCR, mass spectrometry and ELISA. Importantly, pharmacological clearance of senescent cells by induction of apoptosis in fibrotic ATII cells or ex vivo three-dimensional lung tissue cultures reduced SASP factors and extracellular matrix markers, while increasing alveolar epithelial markers.These data indicate that alveolar epithelial cell senescence contributes to lung fibrosis development and that senolytic drugs may be a viable therapeutic option for IPF. Twit Text FOAVip Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo ????Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=28775044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28775044 #FOAvip English Wikipedia <ref>{{Cite pmid|28775044 }}</ref> Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo #MMPMID28775044 Lehmann M ; Korfei M ; Mutze K ; Klee S ; Skronska-Wasek W ; Alsafadi HN ; Ota C ; Costa R ; Schiller HB ; Lindner M ; Wagner DE ; Günther A ; Königshoff M Eur Respir J 2017[Aug]; 50 (2 ): ä PMID28775044 show ga Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases with age, and ageing-related mechanisms such as cellular senescence have been proposed as pathogenic drivers. The lung alveolar epithelium represents a major site of tissue injury in IPF and senescence of this cell population is probably detrimental to lung repair. However, the potential pathomechanisms of alveolar epithelial cell senescence and the impact of senolytic drugs on senescent lung cells and fibrosis remain unknown. Here we demonstrate that lung epithelial cells exhibit increased P16 and P21 expression as well as senescence-associated ?-galactosidase activity in experimental and human lung fibrosis tissue and primary cells.Primary fibrotic mouse alveolar epithelial type (AT)II cells secreted increased amounts of senescence-associated secretory phenotype (SASP) factors in vitro, as analysed using quantitative PCR, mass spectrometry and ELISA. Importantly, pharmacological clearance of senescent cells by induction of apoptosis in fibrotic ATII cells or ex vivo three-dimensional lung tissue cultures reduced SASP factors and extracellular matrix markers, while increasing alveolar epithelial markers.These data indicate that alveolar epithelial cell senescence contributes to lung fibrosis development and that senolytic drugs may be a viable therapeutic option for IPF. |*Cellular Senescence [MESH] |Alveolar Epithelial Cells/*drug effects [MESH] |Animals [MESH] |Biomarkers/*metabolism [MESH] |Cyclin-Dependent Kinase Inhibitor p16/genetics/metabolism [MESH] |Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism [MESH] |Humans [MESH] |Idiopathic Pulmonary Fibrosis/*metabolism/pathology [MESH] |Lung/pathology [MESH]Senolytic drugs target alveolar epithelial cell function and attenuate(epmc).pdf DeepDyve Pubget Overpricing