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10.1111/cts.12481 http://scihub22266oqcxt.onion/10.1111/cts.12481 C5593164!5593164 !28675584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28675584 &cmd=llinks): Failed to open stream: HTTP request failed! 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Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis |pdf=|usr=}}{{28675584 }} gab.com Text Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases Reconsidering the Intact Nephron Hypothesis JO: Clin Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=28675584 #FOAvip Drug-dose modification in chronic kidney disease (CKD) utilizes glomerular filtration rate (GFR) with the implicit assumption that multiple renal excretory processes decline in parallel as CKD progresses. We compiled published pharmacokinetic data to evaluate if GFR predicts renal clearance changes as a function of CKD severity. For each drug, we calculated ratio of renal clearance to filtration clearance (Rnf). Of 21 drugs with Rnf >0.74 in subjects with GFR >90 mL/min (implying filtration and secretion), 13 displayed significant change in Rnf vs. GFR (slope of linear regression statistically different from zero), which indicates failure of GFR to predict changes in secretory clearance. The dependence was positive (n = 3; group A) or negative (n = 10; group B). Eight drugs showed no correlation (group C). Investigated drugs were small molecules, mostly hydrophilic, and ionizable, with some characterized as renal transporter substrates. In conclusion, dosing adjustments in CKD require refinement; in addition to GFR, biomarkers of tubular function are needed for secreted drugs. Twit Text FOAVip Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases Reconsidering the Intact Nephron Hypothesis ????Clin Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=28675584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28675584 #FOAvip English Wikipedia <ref>{{Cite pmid|28675584 }}</ref> Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis #MMPMID28675584 Chapron A ; Shen DD ; Kestenbaum BR ; Robinson-Cohen C ; Himmelfarb J ; Yeung CK Clin Transl Sci 2017[Sep]; 10 (5 ): 395-403 PMID28675584 show ga Drug-dose modification in chronic kidney disease (CKD) utilizes glomerular filtration rate (GFR) with the implicit assumption that multiple renal excretory processes decline in parallel as CKD progresses. We compiled published pharmacokinetic data to evaluate if GFR predicts renal clearance changes as a function of CKD severity. For each drug, we calculated ratio of renal clearance to filtration clearance (Rnf). Of 21 drugs with Rnf >0.74 in subjects with GFR >90 mL/min (implying filtration and secretion), 13 displayed significant change in Rnf vs. GFR (slope of linear regression statistically different from zero), which indicates failure of GFR to predict changes in secretory clearance. The dependence was positive (n = 3; group A) or negative (n = 10; group B). Eight drugs showed no correlation (group C). Investigated drugs were small molecules, mostly hydrophilic, and ionizable, with some characterized as renal transporter substrates. In conclusion, dosing adjustments in CKD require refinement; in addition to GFR, biomarkers of tubular function are needed for secreted drugs. |*Models, Biological [MESH] |Glomerular Filtration Rate/*physiology [MESH] |Humans [MESH] |Nephrons/*physiopathology [MESH] |Pharmaceutical Preparations [MESH]Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic (epmc).pdf DeepDyve Pubget Overpricing