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10.3892/ijo.2017.4093

http://scihub22266oqcxt.onion/10.3892/ijo.2017.4093
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C5592879!5592879!28848995
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suck abstract from ncbi

pmid28848995      Int+J+Oncol 2017 ; 51 (4): 1025-34
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  • Rho GTPases as therapeutic targets in cancer (Review) #MMPMID28848995
  • Cardama G; Gonzalez N; Maggio J; Menna PL; Gomez D
  • Int J Oncol 2017[Oct]; 51 (4): 1025-34 PMID28848995show ga
  • Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.
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