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10.3892/ijo.2017.4101 http://scihub22266oqcxt.onion/10.3892/ijo.2017.4101 C5592864!5592864 !28848999     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28848999 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2017 ; 51 (4 ): 1055-1066 Nephropedia Template TP {{tp|p=28848999 |t=2017. YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression |pdf=|usr=}}{{28848999 }} gab.com Text YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28848999 #FOAvip Cancer-associated mesenchymal stem cells (MSCs) are critically involved in tumor development and progression. However, the mechanisms of action for MSCs in cancer remain largely unknown. Herein, we reported that the expression of Yes-associated protein 1 (YAP) was higher in gastric cancer derived mesenchymal stem cells (GC?MSCs) than that in bone marrow derived MSCs (BM?MSCs). YAP knockdown not only inhibited the growth, migration and invasion, and stemness of GC?MSCs, but also suppressed their promoting effect on gastric cancer growth in vitro and in vivo. In addition, the interference of YAP expression in GC?MSCs also attenuated the promoting role of gastric cancer cells in endothelial cell tube formation and migration. Mechanistically, YAP knockdown reduced the activation of ?-catenin and its target genes in gastric cancer cells by GC?MSCs. Taken together, these findings suggest that YAP activation in GC?MSCs plays an important role in promoting gastric cancer progression, which may represent a potential target for gastric cancer therapy. Twit Text FOAVip YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28848999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28848999 #FOAvip English Wikipedia <ref>{{Cite pmid|28848999 }}</ref> YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression #MMPMID28848999 Pan Z ; Tian Y ; Zhang B ; Zhang X ; Shi H ; Liang Z ; Wu P ; Li R ; You B ; Yang L ; Mao F ; Qian H ; Xu W Int J Oncol 2017[Oct]; 51 (4 ): 1055-1066 PMID28848999 show ga Cancer-associated mesenchymal stem cells (MSCs) are critically involved in tumor development and progression. However, the mechanisms of action for MSCs in cancer remain largely unknown. Herein, we reported that the expression of Yes-associated protein 1 (YAP) was higher in gastric cancer derived mesenchymal stem cells (GC?MSCs) than that in bone marrow derived MSCs (BM?MSCs). YAP knockdown not only inhibited the growth, migration and invasion, and stemness of GC?MSCs, but also suppressed their promoting effect on gastric cancer growth in vitro and in vivo. In addition, the interference of YAP expression in GC?MSCs also attenuated the promoting role of gastric cancer cells in endothelial cell tube formation and migration. Mechanistically, YAP knockdown reduced the activation of ?-catenin and its target genes in gastric cancer cells by GC?MSCs. Taken together, these findings suggest that YAP activation in GC?MSCs plays an important role in promoting gastric cancer progression, which may represent a potential target for gastric cancer therapy. |Aged [MESH] |Animals [MESH] |Cell Cycle Proteins [MESH] |Cell Proliferation/physiology [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Heterografts [MESH] |Humans [MESH] |Male [MESH] |Mesenchymal Stem Cells/*metabolism/*pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Middle Aged [MESH] |Neoplastic Stem Cells/*metabolism/*pathology [MESH] |Neovascularization, Pathologic/metabolism/pathology [MESH] |Nuclear Proteins/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Stomach Neoplasms/blood supply/*metabolism/*pathology [MESH]YAP signaling in gastric cancer-derived mesenchymal stem cells is crit(epmc).pdf DeepDyve Pubget Overpricing