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10.3892/ijo.2017.4104 http://scihub22266oqcxt.onion/10.3892/ijo.2017.4104 C5592862!5592862 !28902370     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28902370 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2017 ; 51 (4 ): 1077-1088 Nephropedia Template TP {{tp|p=28902370 |t=2017. Nano Let?7b sensitization of eliminating esophageal cancer stem?like cells is dependent on blockade of Wnt activation of symmetric division |pdf=|usr=}}{{28902370 }} gab.com Text Nano Let 7b sensitization of eliminating esophageal cancer stem like cells is dependent on blockade of Wnt activation of symmetric division JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28902370 #FOAvip The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence. Higher ratios of cancer stem cells indicated later clinical stages, and Wnt signaling activation was more frequent in later esophageal carcinoma. Further in bench studies, we explored the suppressive roles and the mechanisms involved in Let?7 on self-renewal in ECA?109 and ECA?9706 esophageal cancer stem cells. Isolated cancer stem cells naturally divide symmetrically and are therapy resistant. Therapy of fluorouracil and docetaxel both enriched the stem cells, proving the resistant characteristics of cancer stem cells. Wnt activation stimulated more symmetric division of stem cells, resulting in self-renewal promotion, which could be blocked by Let?7 overexpression. Furthermore, enforced Let?7 sensitized the stem cells to chemotherapies in a Wnt pathway inhibition-dependent manner, contributing to Let?7 sensitization of chemotherapeutic response. Wnt activation weakened the suppressive Let?7b through the sponge functions of CCAT-1, forming the negative feedback loop of Let?7b/Wnt/CCAT1. These results identified the crucial participation of stem cells in esophageal cancer occurrence and progression as the potent indicator, and also indicate the potential powerful agent of Let?7 nano-particles in treatment of cancer. Twit Text FOAVip Nano Let 7b sensitization of eliminating esophageal cancer stem like cells is dependent on blockade of Wnt activation of symmetric division ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28902370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28902370 #FOAvip English Wikipedia <ref>{{Cite pmid|28902370 }}</ref> Nano Let?7b sensitization of eliminating esophageal cancer stem?like cells is dependent on blockade of Wnt activation of symmetric division #MMPMID28902370 Pang Y ; Liu J ; Li X ; Zhang Y ; Zhang B ; Zhang J ; Du N ; Xu C ; Liang R ; Ren H ; Tang SC ; Sun X Int J Oncol 2017[Oct]; 51 (4 ): 1077-1088 PMID28902370 show ga The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence. Higher ratios of cancer stem cells indicated later clinical stages, and Wnt signaling activation was more frequent in later esophageal carcinoma. Further in bench studies, we explored the suppressive roles and the mechanisms involved in Let?7 on self-renewal in ECA?109 and ECA?9706 esophageal cancer stem cells. Isolated cancer stem cells naturally divide symmetrically and are therapy resistant. Therapy of fluorouracil and docetaxel both enriched the stem cells, proving the resistant characteristics of cancer stem cells. Wnt activation stimulated more symmetric division of stem cells, resulting in self-renewal promotion, which could be blocked by Let?7 overexpression. Furthermore, enforced Let?7 sensitized the stem cells to chemotherapies in a Wnt pathway inhibition-dependent manner, contributing to Let?7 sensitization of chemotherapeutic response. Wnt activation weakened the suppressive Let?7b through the sponge functions of CCAT-1, forming the negative feedback loop of Let?7b/Wnt/CCAT1. These results identified the crucial participation of stem cells in esophageal cancer occurrence and progression as the potent indicator, and also indicate the potential powerful agent of Let?7 nano-particles in treatment of cancer. |*Wnt Signaling Pathway/drug effects [MESH] |AC133 Antigen/metabolism [MESH] |Aged [MESH] |Aldehyde Dehydrogenase 1 Family [MESH] |Cell Line, Tumor [MESH] |Docetaxel [MESH] |Esophageal Neoplasms/drug therapy/*genetics/metabolism/surgery [MESH] |Female [MESH] |Fluorouracil/pharmacology [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Isoenzymes/metabolism [MESH] |Male [MESH] |MicroRNAs/*genetics [MESH] |Middle Aged [MESH] |Nanomedicine [MESH] |Neoplastic Stem Cells/*cytology/drug effects/metabolism [MESH] |RNA, Long Noncoding/genetics [MESH] |Retinal Dehydrogenase/metabolism [MESH] |Retrospective Studies [MESH]Nano Let?7b sensitization of eliminating esophageal cancer stem?like c(epmc).pdf DeepDyve Pubget Overpricing