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10.3892/ol.2017.6715 http://scihub22266oqcxt.onion/10.3892/ol.2017.6715 C5592852!5592852!28943922     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 14 (4): 4151-7 Nephropedia Template TP {{tp|p=28943922|t=2017. Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway |pdf=|usr=}}{{28943922}} gab.com Text Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28943922 #FOAvip A previous study from our group using an in vivo model demonstrated that diet induced-obesity increases the risk of gastric cancer and may prompt its growth. However, the molecular mechanisms underlying this association remain unclear and require further investigation. The aim of the present study was to investigate the potential molecular mechanisms through which obesity affects gastric cancer growth. In a subcutaneous mouse model, tumors were significantly larger in obese mice compared with non-obese and lean mice. In addition, markedly increased levels of Sirt1 and YAP protein were observed in the nucleus of cells from subcutaneous tumors from obese mice compared with those from lean mice. Murine forestomach carcinoma (MFC) cells treated with 5% sera from obese mice exhibited significantly increased expression of Sirt1 and YAP compared with MFC cells treated with sera from lean mice. In addition, a positive correlation was observed between Sirt1 expression and YAP expression, and between Sirt1 expression and serum visfatin levels in mice. These results suggested that diet-induced obesity could promote murine gastric cancer growth by modulating the Sirt1/YAP signaling pathway. Twit Text FOAVip Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28943922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28943922 #FOAvip English Wikipedia <ref>{{Cite pmid|28943922}}</ref> Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway #MMPMID28943922 Li HJ; Fu JK; Che XM; Fan L; Zhang Y; Bai E Oncol Lett 2017[Oct]; 14 (4): 4151-7 PMID28943922show ga A previous study from our group using an in vivo model demonstrated that diet induced-obesity increases the risk of gastric cancer and may prompt its growth. However, the molecular mechanisms underlying this association remain unclear and require further investigation. The aim of the present study was to investigate the potential molecular mechanisms through which obesity affects gastric cancer growth. In a subcutaneous mouse model, tumors were significantly larger in obese mice compared with non-obese and lean mice. In addition, markedly increased levels of Sirt1 and YAP protein were observed in the nucleus of cells from subcutaneous tumors from obese mice compared with those from lean mice. Murine forestomach carcinoma (MFC) cells treated with 5% sera from obese mice exhibited significantly increased expression of Sirt1 and YAP compared with MFC cells treated with sera from lean mice. In addition, a positive correlation was observed between Sirt1 expression and YAP expression, and between Sirt1 expression and serum visfatin levels in mice. These results suggested that diet-induced obesity could promote murine gastric cancer growth by modulating the Sirt1/YAP signaling pathway. äObesity accelerates murine gastric cancer growth by modulating the Sir(epmc).pdf DeepDyve Pubget Overpricing