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10.1016/j.kint.2016.10.034 http://scihub22266oqcxt.onion/10.1016/j.kint.2016.10.034 C5592833!5592833 !28131398     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28131398 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Int 2017 ; 91 (5 ): 1104-1114 Nephropedia Template TP {{tp|p=28131398 |t=2017. Recombinant ?-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy |pdf=|usr=}}{{28131398 }} gab.com Text Recombinant -Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=28131398 #FOAvip ?-Klotho is highly expressed in the kidney, and its extracellular domain is cleaved and released into the circulation. Chronic kidney disease (CKD) is a state of ?-Klotho deficiency, which exerts multiple negative systemic effects on numerous organs including the cardiovascular system. Since acute kidney injury (AKI) greatly escalates the risk of CKD development, we explored the effect of ?-Klotho on prevention and treatment on post-AKI to CKD progression and cardiovascular disease. Therein, ischemia reperfusion injury-induced AKI was followed by early administration of recombinant ?-Klotho or vehicle starting one day and continued for four days after kidney injury (CKD prevention protocol). A CKD model was generated by unilateral nephrectomy plus contralateral ischemia reperfusion injury. Late administration of ?-Klotho in this model was started four weeks after injury and sustained for 12 weeks (CKD treatment protocol). The prevention protocol precluded AKI to CKD progression and protected the heart from cardiac remodeling in the post-AKI model. One important effect of exogenous ?-Klotho therapy was the restoration of endogenous ?-Klotho levels long after the cessation of exogenous ?-Klotho therapy. The treatment protocol still effectively improved renal function and attenuated cardiac remodeling in CKD, although these parameters did not completely return to normal. In addition, ?-Klotho administration also attenuated high phosphate diet-induced renal and cardiac fibrosis, and improved renal and cardiac function in the absence of pre-existing renal disease. Thus, recombinant ?-Klotho protein is safe and efficacious, and might be a promising prophylactic or therapeutic option for prevention or retardation of AKI-to-CKD progression and uremic cardiomyopathy. Twit Text FOAVip Recombinant -Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=28131398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28131398 #FOAvip English Wikipedia <ref>{{Cite pmid|28131398 }}</ref> Recombinant ?-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy #MMPMID28131398 Hu MC ; Shi M ; Gillings N ; Flores B ; Takahashi M ; Kuro-O M ; Moe OW Kidney Int 2017[May]; 91 (5 ): 1104-1114 PMID28131398 show ga ?-Klotho is highly expressed in the kidney, and its extracellular domain is cleaved and released into the circulation. Chronic kidney disease (CKD) is a state of ?-Klotho deficiency, which exerts multiple negative systemic effects on numerous organs including the cardiovascular system. Since acute kidney injury (AKI) greatly escalates the risk of CKD development, we explored the effect of ?-Klotho on prevention and treatment on post-AKI to CKD progression and cardiovascular disease. Therein, ischemia reperfusion injury-induced AKI was followed by early administration of recombinant ?-Klotho or vehicle starting one day and continued for four days after kidney injury (CKD prevention protocol). A CKD model was generated by unilateral nephrectomy plus contralateral ischemia reperfusion injury. Late administration of ?-Klotho in this model was started four weeks after injury and sustained for 12 weeks (CKD treatment protocol). The prevention protocol precluded AKI to CKD progression and protected the heart from cardiac remodeling in the post-AKI model. One important effect of exogenous ?-Klotho therapy was the restoration of endogenous ?-Klotho levels long after the cessation of exogenous ?-Klotho therapy. The treatment protocol still effectively improved renal function and attenuated cardiac remodeling in CKD, although these parameters did not completely return to normal. In addition, ?-Klotho administration also attenuated high phosphate diet-induced renal and cardiac fibrosis, and improved renal and cardiac function in the absence of pre-existing renal disease. Thus, recombinant ?-Klotho protein is safe and efficacious, and might be a promising prophylactic or therapeutic option for prevention or retardation of AKI-to-CKD progression and uremic cardiomyopathy. |Acute Kidney Injury/blood/complications/*drug therapy/metabolism [MESH] |Animals [MESH] |Biological Therapy/methods [MESH] |Cardiomyopathies/*drug therapy/etiology [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Drug Evaluation, Preclinical [MESH] |Female [MESH] |Fibrosis [MESH] |Glucuronidase/administration & dosage/*metabolism/*therapeutic use [MESH] |Humans [MESH] |Injections, Intraperitoneal [MESH] |Kidney/metabolism/pathology [MESH] |Klotho Proteins [MESH] |Male [MESH] |Mice [MESH] |Myocardium/pathology [MESH] |Recombinant Proteins/therapeutic use [MESH] |Renal Insufficiency, Chronic/blood/complications/*drug therapy/metabolism [MESH]Recombinant ?-Klotho may be prophylactic and therapeutic for acute to (epmc).pdf DeepDyve Pubget Overpricing