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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Chem+Biol 2017 ; 12 (3): 586-600 Nephropedia Template TP
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Subcellular Redox Targeting: Bridging In Vitro and In Vivo Chemical Biology #MMPMID28068059
Long MJC; Poganik JR; Ghosh S; Aye Y
ACS Chem Biol 2017[Mar]; 12 (3): 586-600 PMID28068059show ga
Networks of redox sensor proteins within discrete microdomains regulate the flow of redox signaling. Yet, the inherent reactivity of redox signals complicates the study of specific redox events and pathways by traditional methods. Herein, we review designer chemistries capable of measuring flux and/or mimicking subcellular redox signaling at the cellular and organismal level. Such efforts have begun to decipher the logic underlying organelle-, site-, and target-specific redox signaling in vitro and in vivo. These data highlight chemical biology as a perfect gateway to interrogate how Nature choreographs subcellular redox chemistry to drive precision redox biology.