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10.1016/j.vph.2015.06.013 http://scihub22266oqcxt.onion/10.1016/j.vph.2015.06.013 C5592725!5592725 !26133668     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26133668 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Vascul+Pharmacol 2016 ; 76 (ä): 28-36 Nephropedia Template TP {{tp|p=26133668 |t=2016. The angiotensin receptor blocker losartan reduces coronary arteriole remodeling in type 2 diabetic mice |pdf=|usr=}}{{26133668 }} gab.com Text The angiotensin receptor blocker losartan reduces coronary arteriole remodeling in type 2 diabetic mice JO: Vascul Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26133668 #FOAvip Cardiovascular complications are a leading cause of morbidity and mortality in type 2 diabetes mellitus (T2DM) and are associated with alterations of blood vessel structure and function. Although endothelial dysfunction and aortic stiffness have been documented, little is known about the effects of T2DM on coronary microvascular structural remodeling. The renin-angiotensin-aldosterone system plays an important role in large artery stiffness and mesenteric vessel remodeling in hypertension and T2DM. The goal of this study was to determine whether the blockade of AT1R signaling dictates vascular smooth muscle growth that partially underlies coronary arteriole remodeling in T2DM. Control and db/db mice were given AT1R blocker losartan via drinking water for 4 weeks. Using pressure myography, we found that coronary arterioles from 16-week db/db mice undergo inward hypertrophic remodeling due to increased wall thickness and wall-to-lumen ratio with a decreased lumen diameter. This remodeling was accompanied by decreased elastic modulus (decreased stiffness). Losartan treatment decreased wall thickness, wall-to-lumen ratio, and coronary arteriole cell number in db/db mice. Losartan treatment did not affect incremental elastic modulus. However, losartan improved coronary flow reserve. Our data suggest that Ang II-AT1R signaling mediates, at least in part, coronary arteriole inward hypertrophic remodeling in T2DM without affecting vascular mechanics, further suggesting that targeting the coronary microvasculature in T2DM may help reduce cardiac ischemic events. Twit Text FOAVip The angiotensin receptor blocker losartan reduces coronary arteriole remodeling in type 2 diabetic mice ????Vascul Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26133668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26133668 #FOAvip English Wikipedia <ref>{{Cite pmid|26133668 }}</ref> The angiotensin receptor blocker losartan reduces coronary arteriole remodeling in type 2 diabetic mice #MMPMID26133668 Husarek KE ; Katz PS ; Trask AJ ; Galantowicz ML ; Cismowski MJ ; Lucchesi PA Vascul Pharmacol 2016[Jan]; 76 (ä): 28-36 PMID26133668 show ga Cardiovascular complications are a leading cause of morbidity and mortality in type 2 diabetes mellitus (T2DM) and are associated with alterations of blood vessel structure and function. Although endothelial dysfunction and aortic stiffness have been documented, little is known about the effects of T2DM on coronary microvascular structural remodeling. The renin-angiotensin-aldosterone system plays an important role in large artery stiffness and mesenteric vessel remodeling in hypertension and T2DM. The goal of this study was to determine whether the blockade of AT1R signaling dictates vascular smooth muscle growth that partially underlies coronary arteriole remodeling in T2DM. Control and db/db mice were given AT1R blocker losartan via drinking water for 4 weeks. Using pressure myography, we found that coronary arterioles from 16-week db/db mice undergo inward hypertrophic remodeling due to increased wall thickness and wall-to-lumen ratio with a decreased lumen diameter. This remodeling was accompanied by decreased elastic modulus (decreased stiffness). Losartan treatment decreased wall thickness, wall-to-lumen ratio, and coronary arteriole cell number in db/db mice. Losartan treatment did not affect incremental elastic modulus. However, losartan improved coronary flow reserve. Our data suggest that Ang II-AT1R signaling mediates, at least in part, coronary arteriole inward hypertrophic remodeling in T2DM without affecting vascular mechanics, further suggesting that targeting the coronary microvasculature in T2DM may help reduce cardiac ischemic events. |Angiotensin II/pharmacology [MESH] |Angiotensin Receptor Antagonists/*pharmacology [MESH] |Animals [MESH] |Arterioles/*drug effects/metabolism [MESH] |Blood Pressure/drug effects [MESH] |Coronary Vessels/*drug effects/metabolism [MESH] |Diabetes Mellitus, Experimental/*diet therapy/metabolism [MESH] |Diabetes Mellitus, Type 2/*drug therapy/metabolism [MESH] |Hypertension/drug therapy/metabolism [MESH] |Losartan/*pharmacology [MESH] |Male [MESH] |Mice [MESH] |Microvessels/drug effects/metabolism [MESH] |Muscle, Smooth, Vascular/drug effects/metabolism [MESH] |Pilot Projects [MESH] |Receptor, Angiotensin, Type 1/metabolism [MESH]The angiotensin receptor blocker losartan reduces coronary arteriole r(epmc).pdf DeepDyve Pubget Overpricing