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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Nephrol
2017 ; 6
(5
): 229-235
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English Wikipedia
Prevalence and outcome of acute kidney injury, as defined by the new Kidney
Disease Improving Global Outcomes guideline, in very low birth weight infants
#MMPMID28948160
Al Malla M
; Varghese NV
; AlAbdullatif M
; Narchi H
; Khassawneh M
World J Nephrol
2017[Sep]; 6
(5
): 229-235
PMID28948160
show ga
AIM: To evaluate the prevalence, risk factors and outcome of acute kidney injury
(AKI) in very low birth weight (VLBW) infants. METHODS: In this retrospective
study of VLBW infants, we analyzed the prevalence of AKI, as defined by changes
in serum creatinine and urine output, associated risk factors and outcomes.
RESULTS: A total of 293 VLBW infants (mean gestational age 28.7 wk) were
included, of whom 109 weighed less than 1000 g at birth. The overall prevalence
of AKI was 11.6% (22% in infants with a birth weight under 1000 g and 5.4% those
heavier). A total of 19 (55%) affected infants died, with a mortality rate of 58%
in infant less than 1000 g and 50% in those heavier. After adjusting for
confounding variables, only necrotizing enterocolitis (NEC) remained associated
with AKI, with odds ratio of 4.9 (95%CI: 1.9-18.6). Blood pressure and glomerular
filtration rate (GFR) were not different between affected infants and the others
upon discharge from hospital. A normal GFR was documented in all affected infants
at one year of age. CONCLUSION: Using Kidney Disease Improving Global Outcomes
definition of AKI, it occurred in over 10% of VLBW infants, more commonly in
infants with lower birth weight. NEC was an independent associated risk factor.
Renal function, as defined by GFR, was normal in all surviving affected infants
10 to 12 mo later.