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10.1016/j.mjafi.2016.09.001 http://scihub22266oqcxt.onion/10.1016/j.mjafi.2016.09.001 C5592260!5592260!28924318     free     free     free       Med+J+Armed+Forces+India 2017 ; 73 (2): 167-74 Nephropedia Template TP {{tp|p=28924318|t=2017. Pre-eclampsia: Molecular events to biomarkers |pdf=|usr=}}{{28924318}} gab.com Text Pre-eclampsia: Molecular events to biomarkers JO: Med J Armed Forces India http://www.kidney.de/pget.php?&tw=1&pmid=28924318 #FOAvip Pre-eclampsia is a hypertensive disorder in pregnancy, which accounts for 10?15% of the maternal and perinatal mortality worldwide. Abnormal placental development and tissue hypoxia are its main etiologic factors. The present diagnostic methods of blood pressure monitoring and renal function evaluation are insufficient in the early detection of pre-eclampsia. Since molecular events portent well ahead of the disease onset, biomarker research for the early diagnosis of pre-eclampsia has recently generated ambitious clinical targets. However, no clinically validated biomarker has so far been reported for the prediction of pre-eclampsia. Therefore, this review takes stock of the current understanding of pre-eclampsia from a molecular biology perspective and critically evaluates the following diagnostic potentials claimed for the biomarkers: placental proteins, angiogenic markers, and cell-free fetal DNA (cffDNA) in maternal circulation. Though the emerging evidences in favor of the fetal-specific epigenetic marker, hypermethylated RASSF1A of cffDNA, are highlighted, it pitches for a broader strategy of ?combination biomarker approach? for the reliable forecasting and triaging of pre-eclampsia. Twit Text FOAVip Pre-eclampsia: Molecular events to biomarkers ????Med J Armed Forces India http://www.kidney.de/pget.php?&tw=1&pmid=28924318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924318 #FOAvip English Wikipedia <ref>{{Cite pmid|28924318}}</ref> Pre-eclampsia: Molecular events to biomarkers #MMPMID28924318 Sahai K; Saraswathy S; Yadav TP; Arora D; Krishnan M Med J Armed Forces India 2017[Apr]; 73 (2): 167-74 PMID28924318show ga Pre-eclampsia is a hypertensive disorder in pregnancy, which accounts for 10?15% of the maternal and perinatal mortality worldwide. Abnormal placental development and tissue hypoxia are its main etiologic factors. The present diagnostic methods of blood pressure monitoring and renal function evaluation are insufficient in the early detection of pre-eclampsia. Since molecular events portent well ahead of the disease onset, biomarker research for the early diagnosis of pre-eclampsia has recently generated ambitious clinical targets. However, no clinically validated biomarker has so far been reported for the prediction of pre-eclampsia. Therefore, this review takes stock of the current understanding of pre-eclampsia from a molecular biology perspective and critically evaluates the following diagnostic potentials claimed for the biomarkers: placental proteins, angiogenic markers, and cell-free fetal DNA (cffDNA) in maternal circulation. Though the emerging evidences in favor of the fetal-specific epigenetic marker, hypermethylated RASSF1A of cffDNA, are highlighted, it pitches for a broader strategy of ?combination biomarker approach? for the reliable forecasting and triaging of pre-eclampsia. äPre-eclampsia: Molecular events to biomarkers (epmc).pdf DeepDyve Pubget Overpricing