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10.1016/j.molcel.2017.06.009 http://scihub22266oqcxt.onion/10.1016/j.molcel.2017.06.009 C5592244!5592244 !28689657     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28689657 &cmd=llinks): Failed to open stream: HTTP request failed! 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Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5 |pdf=|usr=}}{{28689657 }} gab.com Text Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5 JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28689657 #FOAvip Extracellular signals are transduced to the cell nucleus by effectors that bind to enhancer complexes to operate transcriptional switches. For example, the Wnt enhanceosome is a multiprotein complex associated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE co-repressors. Wnt-activated ?-catenin binds to TCF to overcome this repression, but how it achieves this is unknown. Here, we discover that this process depends on the HECT E3 ubiquitin ligase Hyd/UBR5, which is required for Wnt signal responses in Drosophila and human cell lines downstream of activated Armadillo/?-catenin. We identify Groucho/TLE as a functionally relevant substrate, whose ubiquitylation by UBR5 is induced by Wnt signaling and conferred by ?-catenin. Inactivation of TLE by UBR5-dependent ubiquitylation also involves VCP/p97, an AAA ATPase regulating the folding of various cellular substrates including ubiquitylated chromatin proteins. Thus, Groucho/TLE ubiquitylation by Hyd/UBR5 is a key prerequisite that enables Armadillo/?-catenin to activate transcription. Twit Text FOAVip Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5 ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28689657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28689657 #FOAvip English Wikipedia <ref>{{Cite pmid|28689657 }}</ref> Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5 #MMPMID28689657 Flack JE ; Mieszczanek J ; Novcic N ; Bienz M Mol Cell 2017[Jul]; 67 (2 ): 181-193.e5 PMID28689657 show ga Extracellular signals are transduced to the cell nucleus by effectors that bind to enhancer complexes to operate transcriptional switches. For example, the Wnt enhanceosome is a multiprotein complex associated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE co-repressors. Wnt-activated ?-catenin binds to TCF to overcome this repression, but how it achieves this is unknown. Here, we discover that this process depends on the HECT E3 ubiquitin ligase Hyd/UBR5, which is required for Wnt signal responses in Drosophila and human cell lines downstream of activated Armadillo/?-catenin. We identify Groucho/TLE as a functionally relevant substrate, whose ubiquitylation by UBR5 is induced by Wnt signaling and conferred by ?-catenin. Inactivation of TLE by UBR5-dependent ubiquitylation also involves VCP/p97, an AAA ATPase regulating the folding of various cellular substrates including ubiquitylated chromatin proteins. Thus, Groucho/TLE ubiquitylation by Hyd/UBR5 is a key prerequisite that enables Armadillo/?-catenin to activate transcription. |*Transcription, Genetic [MESH] |*Wnt Signaling Pathway [MESH] |Adenosine Triphosphatases/genetics/metabolism [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Armadillo Domain Proteins/genetics/metabolism [MESH] |Basic Helix-Loop-Helix Transcription Factors/genetics/*metabolism [MESH] |CRISPR-Cas Systems [MESH] |Cell Cycle Proteins/genetics/metabolism [MESH] |Co-Repressor Proteins/genetics/*metabolism [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster/*enzymology/genetics [MESH] |Gene Knockdown Techniques [MESH] |HCT116 Cells [MESH] |HEK293 Cells [MESH] |HeLa Cells [MESH] |Humans [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH] |Protein Stability [MESH] |Proteolysis [MESH] |Repressor Proteins/genetics/*metabolism [MESH] |Transcription Factors/genetics/metabolism [MESH] |Transcriptional Activation [MESH] |Transfection [MESH] |Ubiquitin-Protein Ligases/genetics/*metabolism [MESH] |Ubiquitination [MESH] |Valosin Containing Protein [MESH]Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT(epmc).pdf DeepDyve Pubget Overpricing