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10.1155/2017/6193106 http://scihub22266oqcxt.onion/10.1155/2017/6193106 C5591999!5591999 !28928774     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28928774 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28928774 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cells+Int 2017 ; 2017 (ä): 6193106 Nephropedia Template TP {{tp|p=28928774 |t=2017. Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-?/ERK/p90RSK Signalling |pdf=|usr=}}{{28928774 }} gab.com Text Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR- /ERK/p90RSK Signalling JO: Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=28928774 #FOAvip Y-box protein-1 (YB-1) is a highly conserved transcription factor that is involved in multiple biological processes via transcriptional regulation of several genes, including p53, cyclin D1, and EGFR. YB-1 has been reported to be overexpressed in injured livers. This study aims to explore the functions of YB-1 in hepatic progenitor cells (HPCs). Herein, chromatin immunoprecipitation sequencing (ChIP-sequencing) and RNA-sequencing assays identified that YB-1 participated in the biological adhesion process and ECM-receptor interactions in HPCs. Further study demonstrated that YB-1 modulated the expression of extracellular matrix components in HPCs. ChIP-sequencing assays established that PDGFR-? was a target gene of YB-1, and luciferase reporter assays confirmed that YB-1 negatively regulated PDGFR-? promoter activity in HPCs. In addition, PDGFR-? can regulate the expression of collagen I through ERK/p90RSK signalling, and disruption of the signalling pathway with a PDGFR-? inhibitor or ERK1/2 inhibitor abolished the regulatory effect of PDGFR-? on collagen I expression in HPCs. Conclusively, YB-1 can modulate the expression of collagen I in HPCs via direct binding to the PDGFR-? promoter, negatively regulating its expression. In addition, the ERK/p90RSK axis serves as the downstream signalling pathway of PDGFR-?. Twit Text FOAVip Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR- /ERK/p90RSK Signalling ????Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=28928774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28928774 #FOAvip English Wikipedia <ref>{{Cite pmid|28928774 }}</ref> Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-?/ERK/p90RSK Signalling #MMPMID28928774 Li F ; Ma Z ; Liu H ; Zhang Q ; Cai X ; Qu Y ; Xu M ; Lu L Stem Cells Int 2017[]; 2017 (ä): 6193106 PMID28928774 show ga Y-box protein-1 (YB-1) is a highly conserved transcription factor that is involved in multiple biological processes via transcriptional regulation of several genes, including p53, cyclin D1, and EGFR. YB-1 has been reported to be overexpressed in injured livers. This study aims to explore the functions of YB-1 in hepatic progenitor cells (HPCs). Herein, chromatin immunoprecipitation sequencing (ChIP-sequencing) and RNA-sequencing assays identified that YB-1 participated in the biological adhesion process and ECM-receptor interactions in HPCs. Further study demonstrated that YB-1 modulated the expression of extracellular matrix components in HPCs. ChIP-sequencing assays established that PDGFR-? was a target gene of YB-1, and luciferase reporter assays confirmed that YB-1 negatively regulated PDGFR-? promoter activity in HPCs. In addition, PDGFR-? can regulate the expression of collagen I through ERK/p90RSK signalling, and disruption of the signalling pathway with a PDGFR-? inhibitor or ERK1/2 inhibitor abolished the regulatory effect of PDGFR-? on collagen I expression in HPCs. Conclusively, YB-1 can modulate the expression of collagen I in HPCs via direct binding to the PDGFR-? promoter, negatively regulating its expression. In addition, the ERK/p90RSK axis serves as the downstream signalling pathway of PDGFR-?. äY-box Protein-1 Regulates the Expression of Collagen I in Hepatic Prog(epmc).pdf DeepDyve Pubget Overpricing