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10.3389/fimmu.2017.01056

http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01056
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C5591887!5591887!28928736
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suck abstract from ncbi


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pmid28928736      Front+Immunol 2017 ; 8 (ä): ä
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  • Selective IgM Deficiency?An Underestimated Primary Immunodeficiency #MMPMID28928736
  • Gupta S; Gupta A
  • Front Immunol 2017[]; 8 (ä): ä PMID28928736show ga
  • Although selective IgM deficiency (SIGMD) was described almost five decades ago, it was largely ignored as a primary immunodeficiency. SIGMD is defined as serum IgM levels below two SD of mean with normal serum IgG and IgA. It appears to be more common than originally realized. SIGMD is observed in both children and adults. Patients with SIGMD may be asymptomatic; however, approximately 80% of patients with SIGMD present with infections with bacteria, viruses, fungi, and protozoa. There is an increased frequency of allergic and autoimmune diseases in SIGMD. A number of B cell subset abnormalities have been reported and impaired specific antibodies to Streptococcus pneumoniae responses are observed in more than 45% of cases. Innate immunity, T cells, T cell subsets, and T cell functions are essentially normal. The pathogenesis of SIGMD remains unclear. Mice selectively deficient in secreted IgM are also unable to control infections from bacterial, viral, and fungal pathogens, and develop autoimmunity. Immunological and clinical similarities and differences between mouse models of deficiency of secreted IgM and humans with SIGMD have been discussed. Patients with SIGMD presenting with recurrent infections and specific antibody deficiency responses appear to improve clinically on immunoglobulin therapy.
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