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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arch+Gynecol+Obstet
2017 ; 296
(4
): 661-677
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Comparison of the effect between pioglitazone and metformin in treating patients
with PCOS:a meta-analysis
#MMPMID28770353
Xu Y
; Wu Y
; Huang Q
Arch Gynecol Obstet
2017[Oct]; 296
(4
): 661-677
PMID28770353
show ga
BACKGROUND: Pioglitazone was used to treat patients of PCOS in many researches,
but the treatment has not been recognized by public or recommended by all the
guidelines. METHOD: We conducted a meta-analysis of the related literatures to
objectively evaluate the clinical effectiveness and safety by comparing
pioglitazone with metformin administrated by PCOS patients. Searches were
performed in Cochrane Library, EMBASE and PubMed (last updated December 2016).
RESULTS: Eleven studies among 486 related articles were identified through
searches. Fixed effects and random effects models were used to calculate the
overall risk estimates. The results of the meta-analysis suggest that improvement
of the menstrual cycle and ovulation in pioglitazone treatment group was better
than metformin group [OR = 2.31, 95% CI (1.37, 3.91), P < 0.001, I (2) = 41.8%].
Improvement of the F-G scores in metformin treatment group was better than
pioglitazone group [SMD = 0.29, 95% CI (0.0, 0.59), P = 0.048, I (2) = 0.0%]. BMI
was more elevated in pioglitazone group than in metformin group [SMD = 0.83, 95%
CI (0.24, 1.41), P = 0.006, I (2) = 82.8%]. There were no significant differences
of the other data between the two groups. CONCLUSIONS: This meta-analysis
indicated that pioglitazone ameliorated menstrual cycle and ovulation better than
metformin and metformin ameliorated BMI and F-G scores better than pioglitazone
in treating patients with PCOS. Pioglitazone might be a good choice for the
patients with PCOS who were intolerant or invalid to metformin for the treatment.
|Blood Glucose/metabolism
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Hypoglycemic Agents/*therapeutic use
[MESH]
|Metformin/adverse effects/*therapeutic use
[MESH]