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2017 ; 8
(ä): 627
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Nature s Electric Potential: A Systematic Review of the Role of Bioelectricity in
Wound Healing and Regenerative Processes in Animals, Humans, and Plants
#MMPMID28928669
Tyler SEB
Front Physiol
2017[]; 8
(ä): 627
PMID28928669
show ga
Natural endogenous voltage gradients not only predict and correlate with growth
and development but also drive wound healing and regeneration processes. This
review summarizes the existing literature for the nature, sources, and
transmission of information-bearing bioelectric signals involved in controlling
wound healing and regeneration in animals, humans, and plants. It emerges that
some bioelectric characteristics occur ubiquitously in a range of animal and
plant species. However, the limits of similarities are probed to give a realistic
assessment of future areas to be explored. Major gaps remain in our knowledge of
the mechanistic basis for these processes, on which regenerative therapies
ultimately depend. In relation to this, it is concluded that the mapping of
voltage patterns and the processes generating them is a promising future research
focus, to probe three aspects: the role of wound/regeneration currents in
relation to morphology; the role of endogenous flux changes in driving wound
healing and regeneration; and the mapping of patterns in organisms of extreme
longevity, in contrast with the aberrant voltage patterns underlying impaired
healing, to inform interventions aimed at restoring them.