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10.1038/s41598-017-10390-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-10390-2 C5591270!5591270 !28887454     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28887454 &cmd=llinks): Failed to open stream: HTTP request failed! 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The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction |pdf=|usr=}}{{28887454 }} gab.com Text The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28887454 #FOAvip NaPi-IIb/Slc34a2 is a Na(+)-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells. Its abundance is regulated by dietary phosphate, being high during dietary phosphate restriction. Intestinal ablation of NaPi-IIb in mice leads to increased fecal excretion of phosphate, which is compensated by enhanced renal reabsorption. Here we compared the adaptation to dietary phosphate of wild type (WT) and NaPi-IIb(-/-) mice. High phosphate diet (HPD) increased fecal and urinary excretion of phosphate in both groups, though NaPi-IIb(-/-) mice still showed lower urinary excretion than WT. In both genotypes low dietary phosphate (LDP) resulted in reduced fecal excretion and almost undetectable urinary excretion of phosphate. Consistently, the expression of renal cotransporters after prolonged LDP was similar in both groups. Plasma phosphate declined more rapidly in NaPi-IIb(-/-) mice upon LDP, though both genotypes had comparable levels of 1,25(OH)(2)vitamin D(3), parathyroid hormone and fibroblast growth factor 23. Instead, NaPi-IIb(-/-) mice fed LDP had exacerbated hypercalciuria, higher urinary excretion of corticosterone and deoxypyridinoline, lower bone mineral density and higher number of osteoclasts. These data suggest that during dietary phosphate restriction NaPi-IIb-mediated intestinal absorption prevents excessive demineralization of bone as an alternative source of phosphate. Twit Text FOAVip The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28887454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28887454 #FOAvip English Wikipedia <ref>{{Cite pmid|28887454 }}</ref> The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction #MMPMID28887454 Knöpfel T ; Pastor-Arroyo EM ; Schnitzbauer U ; Kratschmar DV ; Odermatt A ; Pellegrini G ; Hernando N ; Wagner CA Sci Rep 2017[Sep]; 7 (1 ): 11018 PMID28887454 show ga NaPi-IIb/Slc34a2 is a Na(+)-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells. Its abundance is regulated by dietary phosphate, being high during dietary phosphate restriction. Intestinal ablation of NaPi-IIb in mice leads to increased fecal excretion of phosphate, which is compensated by enhanced renal reabsorption. Here we compared the adaptation to dietary phosphate of wild type (WT) and NaPi-IIb(-/-) mice. High phosphate diet (HPD) increased fecal and urinary excretion of phosphate in both groups, though NaPi-IIb(-/-) mice still showed lower urinary excretion than WT. In both genotypes low dietary phosphate (LDP) resulted in reduced fecal excretion and almost undetectable urinary excretion of phosphate. Consistently, the expression of renal cotransporters after prolonged LDP was similar in both groups. Plasma phosphate declined more rapidly in NaPi-IIb(-/-) mice upon LDP, though both genotypes had comparable levels of 1,25(OH)(2)vitamin D(3), parathyroid hormone and fibroblast growth factor 23. Instead, NaPi-IIb(-/-) mice fed LDP had exacerbated hypercalciuria, higher urinary excretion of corticosterone and deoxypyridinoline, lower bone mineral density and higher number of osteoclasts. These data suggest that during dietary phosphate restriction NaPi-IIb-mediated intestinal absorption prevents excessive demineralization of bone as an alternative source of phosphate. |*Bone Density [MESH] |Animals [MESH] |Bone and Bones/*physiology [MESH] |Diet/*methods [MESH] |Epithelial Cells/*enzymology/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Phosphates/*administration & dosage/blood [MESH] |Plasma/chemistry [MESH]The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to(epmc).pdf DeepDyve Pubget Overpricing