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10.1038/s41467-017-00609-1 http://scihub22266oqcxt.onion/10.1038/s41467-017-00609-1 C5591266!5591266!28887441     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28887441|t=2017. HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells |pdf=|usr=}}{{28887441}} gab.com Text HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28887441 #FOAvip HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell clones. Here, we show that in 30/87 (34%) patients under combination antiretroviral therapy, BACH2, and STAT5B are activated by insertions triggering the formation of mRNAs that contain viral sequences fused by splicing to their first protein-coding exon. These chimeric mRNAs, predicted to express full-length proteins, are enriched in T regulatory and T central memory cells, but not in other T lymphocyte subsets or monocytes. Overexpression of BACH2 or STAT5B in primary T regulatory cells increases their proliferation and survival without compromising their function. Hence, we provide evidence that HIV-1-mediated insertional activation of BACH2 and STAT5B favor the persistence of a viral reservoir in T regulatory cells in patients under combination antiretroviral therapy. Twit Text FOAVip HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28887441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28887441 #FOAvip English Wikipedia <ref>{{Cite pmid|28887441}}</ref> HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells #MMPMID28887441 Cesana D; Santoni de Sio FR; Rudilosso L; Gallina P; Calabria A; Beretta S; Merelli I; Bruzzesi E; Passerini L; Nozza S; Vicenzi E; Poli G; Gregori S; Tambussi G; Montini E Nat Commun 2017[]; 8 (ä): ä PMID28887441show ga HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell clones. Here, we show that in 30/87 (34%) patients under combination antiretroviral therapy, BACH2, and STAT5B are activated by insertions triggering the formation of mRNAs that contain viral sequences fused by splicing to their first protein-coding exon. These chimeric mRNAs, predicted to express full-length proteins, are enriched in T regulatory and T central memory cells, but not in other T lymphocyte subsets or monocytes. Overexpression of BACH2 or STAT5B in primary T regulatory cells increases their proliferation and survival without compromising their function. Hence, we provide evidence that HIV-1-mediated insertional activation of BACH2 and STAT5B favor the persistence of a viral reservoir in T regulatory cells in patients under combination antiretroviral therapy. äHIV-1-mediated insertional activation of STAT5B and BACH2 trigger vira(epmc).pdf DeepDyve Pubget Overpricing