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10.1038/s41467-017-00609-1 http://scihub22266oqcxt.onion/10.1038/s41467-017-00609-1 C5591266!5591266 !28887441     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28887441 &cmd=llinks): Failed to open stream: HTTP request failed! 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HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells |pdf=|usr=}}{{28887441 }} gab.com Text HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28887441 #FOAvip HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell clones. Here, we show that in 30/87 (34%) patients under combination antiretroviral therapy, BACH2, and STAT5B are activated by insertions triggering the formation of mRNAs that contain viral sequences fused by splicing to their first protein-coding exon. These chimeric mRNAs, predicted to express full-length proteins, are enriched in T regulatory and T central memory cells, but not in other T lymphocyte subsets or monocytes. Overexpression of BACH2 or STAT5B in primary T regulatory cells increases their proliferation and survival without compromising their function. Hence, we provide evidence that HIV-1-mediated insertional activation of BACH2 and STAT5B favor the persistence of a viral reservoir in T regulatory cells in patients under combination antiretroviral therapy.HIV insertions in hematopoietic cells are enriched in BACH2 or MLK2 genes, but the selective advantages conferred are unknown. Here, the authors show that BACH2 and additionally STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence. Twit Text FOAVip HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28887441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28887441 #FOAvip English Wikipedia <ref>{{Cite pmid|28887441 }}</ref> HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells #MMPMID28887441 Cesana D ; Santoni de Sio FR ; Rudilosso L ; Gallina P ; Calabria A ; Beretta S ; Merelli I ; Bruzzesi E ; Passerini L ; Nozza S ; Vicenzi E ; Poli G ; Gregori S ; Tambussi G ; Montini E Nat Commun 2017[Sep]; 8 (1 ): 498 PMID28887441 show ga HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell clones. Here, we show that in 30/87 (34%) patients under combination antiretroviral therapy, BACH2, and STAT5B are activated by insertions triggering the formation of mRNAs that contain viral sequences fused by splicing to their first protein-coding exon. These chimeric mRNAs, predicted to express full-length proteins, are enriched in T regulatory and T central memory cells, but not in other T lymphocyte subsets or monocytes. Overexpression of BACH2 or STAT5B in primary T regulatory cells increases their proliferation and survival without compromising their function. Hence, we provide evidence that HIV-1-mediated insertional activation of BACH2 and STAT5B favor the persistence of a viral reservoir in T regulatory cells in patients under combination antiretroviral therapy.HIV insertions in hematopoietic cells are enriched in BACH2 or MLK2 genes, but the selective advantages conferred are unknown. Here, the authors show that BACH2 and additionally STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence. |Anti-HIV Agents/therapeutic use [MESH] |Basic-Leucine Zipper Transcription Factors/*genetics [MESH] |Cells, Cultured [MESH] |Disease Reservoirs/virology [MESH] |Gene Expression Regulation [MESH] |HEK293 Cells [MESH] |HIV Infections/drug therapy/*genetics/virology [MESH] |HIV-1/drug effects/*genetics/physiology [MESH] |Humans [MESH] |Mutagenesis, Insertional [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |STAT5 Transcription Factor/*genetics [MESH] |T-Lymphocytes, Regulatory/drug effects/*metabolism/virology [MESH]HIV-1-mediated insertional activation of STAT5B and BACH2 trigger vira(epmc).pdf DeepDyve Pubget Overpricing