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2017 ; 7
(1
): 11021
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LNGFR targets the Wnt/?-catenin pathway and promotes the osteogenic
differentiation in rat ectomesenchymal stem cells
#MMPMID28887537
Li G
; Liu J
; Wang Y
; Yang K
; Zhao M
; Xiao Y
; Wen X
; Liu L
Sci Rep
2017[Sep]; 7
(1
): 11021
PMID28887537
show ga
Considerable evidence has shown that the Wnt/?-catenin pathway is involved in
osteogenic differentiation in various stem cells. However, the role of
Wnt/?-catenin pathway in regulating the osteogenic differentiation of rat
ectomesenchymal stem cells (EMSCs), which are considered to be the progenitors of
dental mesenchymal stem cells, remains unknown. In this study, we demonstrated
that nuclear ?-catenin was upregulated during EMSC osteogenic differentiation.
The Wnt signalling inhibitor IWR-1-endo inhibited EMSC osteogenic
differentiation, while the Wnt signalling agonist SKL2001 promoted it. Moreover,
nuclear ?-catenin was further upregulated by the overexpression of low-affinity
nerve growth factor receptor (LNGFR) during EMSC osteogenic differentiation.
Further experiments demonstrated that LNGFR overexpression enhanced EMSC
osteogenic differentiation, while LNGFR silencing decreased it. Additionally,
IWR-1-endo attenuated LNGFR-enhanced EMSC osteogenic differentiation.
Collectively, our data reveal that LNGFR targets the Wnt/?-catenin pathway and
positively regulates EMSC osteogenic differentiation, suggesting that
Wnt/?-catenin pathway may be involved in the development of teeth and that the
targeting Wnt/?-catenin pathway may have great potential for applications in
dental tissue engineering regeneration.
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