Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-11233-w http://scihub22266oqcxt.onion/10.1038/s41598-017-11233-w C5591217!5591217!28887478     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28887478|t=2017. Stat3 as a potential therapeutic target for rheumatoid arthritis |pdf=|usr=}}{{28887478}} gab.com Text Stat3 as a potential therapeutic target for rheumatoid arthritis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28887478 #FOAvip Rheumatoid arthritis (RA) is a multi-factorial disease characterized by chronic inflammation and destruction of multiple joints. To date, various biologic treatments for RA such as anti-tumor necrosis factor alpha antibodies have been developed; however, mechanisms underlying RA development remain unclear and targeted therapy for this condition has not been established. Here, we provide evidence that signal transducer and activator of transcription 3 (Stat3) promotes inflammation and joint erosion in a mouse model of arthritis. Stat3 global KO mice show early embryonic lethality; thus, we generated viable Stat3 conditional knockout adult mice and found that they were significantly resistant to collagen-induced arthritis (CIA), the most common RA model, compared with controls. We then used an in vitro culture system to screen ninety-six existing drugs to select Stat3 inhibitors and selected five candidate inhibitors. Among them, three significantly inhibited development of arthritis and joint erosion in CIA wild-type mice. These findings suggest that Stat3 inhibitors may serve as promising drugs for RA therapy. Twit Text FOAVip Stat3 as a potential therapeutic target for rheumatoid arthritis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28887478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28887478 #FOAvip English Wikipedia <ref>{{Cite pmid|28887478}}</ref> Stat3 as a potential therapeutic target for rheumatoid arthritis #MMPMID28887478 Oike T; Sato Y; Kobayashi T; Miyamoto K; Nakamura S; Kaneko Y; Kobayashi S; Harato K; Saya H; Matsumoto M; Nakamura M; Niki Y; Miyamoto T Sci Rep 2017[]; 7 (ä): ä PMID28887478show ga Rheumatoid arthritis (RA) is a multi-factorial disease characterized by chronic inflammation and destruction of multiple joints. To date, various biologic treatments for RA such as anti-tumor necrosis factor alpha antibodies have been developed; however, mechanisms underlying RA development remain unclear and targeted therapy for this condition has not been established. Here, we provide evidence that signal transducer and activator of transcription 3 (Stat3) promotes inflammation and joint erosion in a mouse model of arthritis. Stat3 global KO mice show early embryonic lethality; thus, we generated viable Stat3 conditional knockout adult mice and found that they were significantly resistant to collagen-induced arthritis (CIA), the most common RA model, compared with controls. We then used an in vitro culture system to screen ninety-six existing drugs to select Stat3 inhibitors and selected five candidate inhibitors. Among them, three significantly inhibited development of arthritis and joint erosion in CIA wild-type mice. These findings suggest that Stat3 inhibitors may serve as promising drugs for RA therapy. äStat3 as a potential therapeutic target for rheumatoid arthritis (epmc).pdf DeepDyve Pubget Overpricing