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10.3390/bioengineering4020046 http://scihub22266oqcxt.onion/10.3390/bioengineering4020046 C5590483!5590483!28952525     free     free     free       Bioengineering+(Basel) 2017 ; 4 (2): ä Nephropedia Template TP {{tp|p=28952525|t=2017. Microtechnology-Based Multi-Organ Models |pdf=|usr=}}{{28952525}} gab.com Text Microtechnology-Based Multi-Organ Models JO: Bioengineering (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28952525 #FOAvip Drugs affect the human body through absorption, distribution, metabolism, and elimination (ADME) processes. Due to their importance, the ADME processes need to be studied to determine the efficacy and side effects of drugs. Various in vitro model systems have been developed and used to realize the ADME processes. However, conventional model systems have failed to simulate the ADME processes because they are different from in vivo, which has resulted in a high attrition rate of drugs and a decrease in the productivity of new drug development. Recently, a microtechnology-based in vitro system called ?organ-on-a-chip? has been gaining attention, with more realistic cell behavior and physiological reactions, capable of better simulating the in vivo environment. Furthermore, multi-organ-on-a-chip models that can provide information on the interaction between the organs have been developed. The ultimate goal is the development of a ?body-on-a-chip?, which can act as a whole body model. In this review, we introduce and summarize the current progress in the development of multi-organ models as a foundation for the development of body-on-a-chip. Twit Text FOAVip Microtechnology-Based Multi-Organ Models ????Bioengineering (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28952525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28952525 #FOAvip English Wikipedia <ref>{{Cite pmid|28952525}}</ref> Microtechnology-Based Multi-Organ Models #MMPMID28952525 Lee SH; Sung JH Bioengineering (Basel) 2017[Jun]; 4 (2): ä PMID28952525show ga Drugs affect the human body through absorption, distribution, metabolism, and elimination (ADME) processes. Due to their importance, the ADME processes need to be studied to determine the efficacy and side effects of drugs. Various in vitro model systems have been developed and used to realize the ADME processes. However, conventional model systems have failed to simulate the ADME processes because they are different from in vivo, which has resulted in a high attrition rate of drugs and a decrease in the productivity of new drug development. Recently, a microtechnology-based in vitro system called ?organ-on-a-chip? has been gaining attention, with more realistic cell behavior and physiological reactions, capable of better simulating the in vivo environment. Furthermore, multi-organ-on-a-chip models that can provide information on the interaction between the organs have been developed. The ultimate goal is the development of a ?body-on-a-chip?, which can act as a whole body model. In this review, we introduce and summarize the current progress in the development of multi-organ models as a foundation for the development of body-on-a-chip. äMicrotechnology-Based Multi-Organ Models (epmc).pdf DeepDyve Pubget Overpricing