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2017 ; 7
(1
): 10884
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Comparison of APACHE IV with APACHE II, SAPS 3, MELD, MELD-Na, and CTP scores in
predicting mortality after liver transplantation
#MMPMID28883401
Lee H
; Yoon S
; Oh SY
; Shin J
; Kim J
; Jung CW
; Ryu HG
Sci Rep
2017[Sep]; 7
(1
): 10884
PMID28883401
show ga
The Acute Physiology and Chronic Health Evaluation (APACHE) IV score and
Simplified Acute Physiology Score (SAPS) 3 include liver transplantation as a
diagnostic category. The performance of APACHE IV-liver transplantation (LT)
specific predicted mortality, SAPS 3, APACHE II, Model for End-stage Liver
Disease (MELD)-Na, MELD, and CTP scores in predicting in-hospital and 1 year
mortality in liver transplant patients was compared using 590 liver
transplantations in a single university hospital. In-hospital mortality and 1
year mortality were 2.9% and 4.2%, respectively. The APACHE IV-LT specific
predicted mortality showed better performance in predicting in-hospital mortality
(AUC 0.91, 95% CI [0.86-0.96]) compared to SAPS 3 (AUC 0.78, 95% CI [0.66-0.90],
p?=?0.01), MELD-Na (AUC 0.74, 95% CI [0.57-0.86], p?=?0.01), and CTP (AUC 0.68,
95% CI [0.54-0.81], p?=?0.01). The APACHE IV-LT specific predicted mortality
showed better performance in predicting 1 year mortality (AUC 0.83, 95% CI
[0.76-0.9]) compared to MELD-Na (AUC 0.67, 95% CI [0.55-0.79], p?=?0.04) and CTP
(AUC 0.64, 95% CI [0.53-0.75], p?=?0.03), and also in all MELD groups and in both
living and deceased donor transplantation. The APACHE IV-LT specific predicted
mortality showed better performance in predicting in-hospital and 1 year
mortality after liver transplantation.