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10.1038/s41467-017-00604-6 http://scihub22266oqcxt.onion/10.1038/s41467-017-00604-6 C5589884!5589884!28883467     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28883467|t=2017. Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis |pdf=|usr=}}{{28883467}} gab.com Text Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28883467 #FOAvip The hypothalamic?pituitary?thyroid (HPT) axis maintains circulating thyroid hormone levels in a narrow physiological range. As axons containing thyrotropin-releasing hormone (TRH) terminate on hypothalamic tanycytes, these specialized glial cells have been suggested to influence the activity of the HPT axis, but their exact role remained enigmatic. Here, we demonstrate that stimulation of the TRH receptor 1 increases intracellular calcium in tanycytes of the median eminence via G?q/11 proteins. Activation of G?q/11 pathways increases the size of tanycyte endfeet that shield pituitary vessels and induces the activity of the TRH-degrading ectoenzyme. Both mechanisms may limit the TRH release to the pituitary. Indeed, blocking TRH signaling in tanycytes by deleting G?q/11 proteins in vivo enhances the response of the HPT axis to the chemogenetic activation of TRH neurons. In conclusion, we identify new TRH- and G?q/11-dependent mechanisms in the median eminence by which tanycytes control the activity of the HPT axis. Twit Text FOAVip Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28883467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28883467 #FOAvip English Wikipedia <ref>{{Cite pmid|28883467}}</ref> Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis #MMPMID28883467 Müller-Fielitz H; Stahr M; Bernau M; Richter M; Abele S; Krajka V; Benzin A; Wenzel J; Kalies K; Mittag J; Heuer H; Offermanns S; Schwaninger M Nat Commun 2017[]; 8 (ä): ä PMID28883467show ga The hypothalamic?pituitary?thyroid (HPT) axis maintains circulating thyroid hormone levels in a narrow physiological range. As axons containing thyrotropin-releasing hormone (TRH) terminate on hypothalamic tanycytes, these specialized glial cells have been suggested to influence the activity of the HPT axis, but their exact role remained enigmatic. Here, we demonstrate that stimulation of the TRH receptor 1 increases intracellular calcium in tanycytes of the median eminence via G?q/11 proteins. Activation of G?q/11 pathways increases the size of tanycyte endfeet that shield pituitary vessels and induces the activity of the TRH-degrading ectoenzyme. Both mechanisms may limit the TRH release to the pituitary. Indeed, blocking TRH signaling in tanycytes by deleting G?q/11 proteins in vivo enhances the response of the HPT axis to the chemogenetic activation of TRH neurons. In conclusion, we identify new TRH- and G?q/11-dependent mechanisms in the median eminence by which tanycytes control the activity of the HPT axis. äTanycytes control the hormonal output of the hypothalamic-pituitary-th(epmc).pdf DeepDyve Pubget Overpricing