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10.1007/s40520-016-0689-0

http://scihub22266oqcxt.onion/10.1007/s40520-016-0689-0
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suck abstract from ncbi


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pmid27896796      Aging+Clin+Exp+Res 2017 ; 29 (5): 927-33
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  • Development and validation of a frailty index in the Longitudinal Aging Study Amsterdam #MMPMID27896796
  • Hoogendijk EO; Theou O; Rockwood K; Onwuteaka-Philipsen BD; Deeg DJH; Huisman M
  • Aging Clin Exp Res 2017[]; 29 (5): 927-33 PMID27896796show ga
  • Background: Frailty is a state of increased vulnerability to adverse outcomes. The frailty index (FI), defined by the deficit accumulation approach, is a sensitive instrument to measure levels of frailty, and therefore important for longitudinal studies of aging. Aims: To develop an FI in the Longitudinal Aging Study Amsterdam (LASA), and to examine the predictive validity of this FI for 19-year mortality. Methods: LASA is an ongoing study among Dutch older adults, based on a nationally representative sample. A 32-item FI (LASA?FI) was developed at the second LASA measurement wave (1995?1996) among 2218 people aged 57?88 years. An FI score between 0 and 1 was calculated for each individual. The LASA?FI included health deficits from the physical, mental and cognitive domain and can be constructed for most LASA measurement waves. Associations with 19-year mortality were assessed using Kaplan?Meier curves and Cox proportional hazards models. Results: The mean LASA?FI score was 0.19 (SD = 0.12), with a 99% upper limit of 0.53. Scores were higher in women than men (women = 0.20, SD = 0.13 vs. men = 0.17, SD = 0.11, p < 0.001). The average age-related increase in the log-transformed LASA?FI score was 3.5% per year. In a model adjusted for age and sex, the FI score was significantly associated with 19-year all-cause mortality (HR per 0.01 = 1.03, 95% CI 1.03?1.04, p < 0.001). Discussion/conclusions: The key characteristics of the LASA?FI were in line with findings from previous FI studies in population-based samples of older people. The LASA?FI score was associated with mortality and may serve as an internal and external reference value.
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