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10.1038/s41598-017-11056-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-11056-9 C5589742!5589742!28883439     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28883439|t=2017. T cells display mitochondria hyperpolarization in human type 1 diabetes |pdf=|usr=}}{{28883439}} gab.com Text T cells display mitochondria hyperpolarization in human type 1 diabetes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28883439 #FOAvip T lymphocytes constitute a major effector cell population in autoimmune type 1 diabetes. Despite essential functions of mitochondria in regulating activation, proliferation, and apoptosis of T cells, little is known regarding T cell metabolism in the progression of human type 1 diabetes. In this study, we report, using two independent cohorts, that T cells from patients with type 1 diabetes exhibited mitochondrial inner-membrane hyperpolarization (MHP). Increased MHP was a general phenotype observed in T cell subsets irrespective of prior antigen exposure, and was not correlated with HbA1C levels, subject age, or duration of diabetes. Elevated T cell MHP was not detected in subjects with type 2 diabetes. T cell MHP was associated with increased activation-induced IFN? production, and activation-induced IFN? was linked to mitochondria-specific ROS production. T cells from subjects with type 1 diabetes also exhibited lower intracellular ATP levels. In conclusion, intrinsic mitochondrial dysfunction observed in type 1 diabetes alters mitochondrial ATP and IFN? production; the latter is correlated with ROS generation. These changes impact T cell bioenergetics and function. Twit Text FOAVip T cells display mitochondria hyperpolarization in human type 1 diabetes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28883439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28883439 #FOAvip English Wikipedia <ref>{{Cite pmid|28883439}}</ref> T cells display mitochondria hyperpolarization in human type 1 diabetes #MMPMID28883439 Chen J; Chernatynskaya AV; Li JW; Kimbrell MR; Cassidy RJ; Perry DJ; Muir AB; Atkinson MA; Brusko TM; Mathews CE Sci Rep 2017[]; 7 (ä): ä PMID28883439show ga T lymphocytes constitute a major effector cell population in autoimmune type 1 diabetes. Despite essential functions of mitochondria in regulating activation, proliferation, and apoptosis of T cells, little is known regarding T cell metabolism in the progression of human type 1 diabetes. In this study, we report, using two independent cohorts, that T cells from patients with type 1 diabetes exhibited mitochondrial inner-membrane hyperpolarization (MHP). Increased MHP was a general phenotype observed in T cell subsets irrespective of prior antigen exposure, and was not correlated with HbA1C levels, subject age, or duration of diabetes. Elevated T cell MHP was not detected in subjects with type 2 diabetes. T cell MHP was associated with increased activation-induced IFN? production, and activation-induced IFN? was linked to mitochondria-specific ROS production. T cells from subjects with type 1 diabetes also exhibited lower intracellular ATP levels. In conclusion, intrinsic mitochondrial dysfunction observed in type 1 diabetes alters mitochondrial ATP and IFN? production; the latter is correlated with ROS generation. These changes impact T cell bioenergetics and function. äT cells display mitochondria hyperpolarization in human type 1 diabete(epmc).pdf DeepDyve Pubget Overpricing