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10.1371/journal.ppat.1006461 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006461 C5589267!5589267 !28880920     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28880920 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2017 ; 13 (9 ): e1006461 Nephropedia Template TP {{tp|p=28880920 |t=2017. The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function |pdf=|usr=}}{{28880920 }} gab.com Text The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28880920 #FOAvip Bacterial superantigens (SAgs) cause V?-dependent T-cell proliferation leading to immune dysregulation associated with the pathogenesis of life-threatening infections such as toxic shock syndrome, and necrotizing pneumonia. Previously, we demonstrated that staphylococcal enterotoxin-like toxin X (SElX) from Staphylococcus aureus is a classical superantigen that exhibits T-cell activation in a V?-specific manner, and contributes to the pathogenesis of necrotizing pneumonia. Here, we discovered that SElX can also bind to neutrophils from human and other mammalian species and disrupt IgG-mediated phagocytosis. Site-directed mutagenesis of the conserved sialic acid-binding motif of SElX abolished neutrophil binding and phagocytic killing, and revealed multiple glycosylated neutrophil receptors for SElX binding. Furthermore, the neutrophil binding-deficient mutant of SElX retained its capacity for T-cell activation demonstrating that SElX exhibits mechanistically independent activities on distinct cell populations associated with acquired and innate immunity, respectively. Finally, we demonstrated that the neutrophil-binding activity rather than superantigenicity is responsible for the SElX-dependent virulence observed in a necrotizing pneumonia rabbit model of infection. Taken together, we report the first example of a SAg, that can manipulate both the innate and adaptive arms of the human immune system during S. aureus pathogenesis. Twit Text FOAVip The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28880920 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28880920 #FOAvip English Wikipedia <ref>{{Cite pmid|28880920 }}</ref> The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function #MMPMID28880920 Tuffs SW ; James DBA ; Bestebroer J ; Richards AC ; Goncheva MI ; O'Shea M ; Wee BA ; Seo KS ; Schlievert PM ; Lengeling A ; van Strijp JA ; Torres VJ ; Fitzgerald JR PLoS Pathog 2017[Sep]; 13 (9 ): e1006461 PMID28880920 show ga Bacterial superantigens (SAgs) cause V?-dependent T-cell proliferation leading to immune dysregulation associated with the pathogenesis of life-threatening infections such as toxic shock syndrome, and necrotizing pneumonia. Previously, we demonstrated that staphylococcal enterotoxin-like toxin X (SElX) from Staphylococcus aureus is a classical superantigen that exhibits T-cell activation in a V?-specific manner, and contributes to the pathogenesis of necrotizing pneumonia. Here, we discovered that SElX can also bind to neutrophils from human and other mammalian species and disrupt IgG-mediated phagocytosis. Site-directed mutagenesis of the conserved sialic acid-binding motif of SElX abolished neutrophil binding and phagocytic killing, and revealed multiple glycosylated neutrophil receptors for SElX binding. Furthermore, the neutrophil binding-deficient mutant of SElX retained its capacity for T-cell activation demonstrating that SElX exhibits mechanistically independent activities on distinct cell populations associated with acquired and innate immunity, respectively. Finally, we demonstrated that the neutrophil-binding activity rather than superantigenicity is responsible for the SElX-dependent virulence observed in a necrotizing pneumonia rabbit model of infection. Taken together, we report the first example of a SAg, that can manipulate both the innate and adaptive arms of the human immune system during S. aureus pathogenesis. |*Staphylococcal Infections [MESH] |Animals [MESH] |Enterotoxins/*metabolism [MESH] |Exfoliatins/metabolism/*pharmacology [MESH] |Humans [MESH] |Lymphocyte Activation/immunology [MESH] |Neutrophils/*drug effects/immunology [MESH] |Rabbits [MESH] |Receptors, Antigen, T-Cell, alpha-beta/immunology [MESH] |Staphylococcus aureus/chemistry/metabolism [MESH]The Staphylococcus aureus superantigen SElX is a bifunctional toxin th(epmc).pdf DeepDyve Pubget Overpricing