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Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex #MMPMID27610567
Robinson PJ; Trnka MJ; Bushnell DA; Davis R; Mattei PJ; Burlingame AL; Kornberg RD
Cell 2016[Sep]; 166 (6): 1411-1422.e16 PMID27610567show ga
A complete, 52-protein, 2.5 million Dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed by cryo-electron microscopy and by chemical cross-linking and mass spectrometry. The resulting complete Med-PIC structure reveals two components of functional significance, absent from previous structures, a protein kinase complex and the Mediator-activator interaction region. It thereby shows how the kinase and its target, the C-terminal domain of the polymerase, control Med-PIC interaction and transcription.