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10.1016/j.ekir.2017.03.012 http://scihub22266oqcxt.onion/10.1016/j.ekir.2017.03.012 C5589115!5589115!28920100     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int+Rep 2017 ; 2 (5): 811-20 Nephropedia Template TP {{tp|p=28920100|t=2017. A Urinary Fragment of Mucin-1 Subunit ? Is a Novel Biomarker Associated With Renal Dysfunction in the General Population |pdf=|usr=}}{{28920100}} gab.com Text A Urinary Fragment of Mucin-1 Subunit Is a Novel Biomarker Associated With Renal Dysfunction in the General Population JO: Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=28920100 #FOAvip Introduction: Sequencing peptides included in the urinary proteome identifies the parent proteins and may reveal mechanisms underlying the pathophysiology of chronic kidney disease. Methods: In 805 randomly recruited Flemish individuals (50.8% women; mean age, 51.1 years), we determined the estimated glomerular filtration rate (eGFR) from serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We categorized eGFR according to the National Kidney Foundation Kidney Disease Outcomes Quality Initiative guideline. We analyzed 74 sequenced urinary peptides with a detectable signal in more than 95% of participants. Follow-up measurements of eGFR were available in 597 participants. Results: In multivariable analyses, baseline eGFR decreased (P ? 0.022) with urinary fragments of mucin-1 (standardized association size expressed in ml/min/1.73 m2, ?4.48), collagen III (?2.84), and fibrinogen (?1.70) and was bi-directionally associated (P ? 0.0006) with 2 urinary collagen I fragments (+2.28 and ?3.20). The eGFR changes over 5 years (follow-up minus baseline) resulted in consistent estimates (P ? 0.025) for mucin-1 (?1.85), collagen (?1.37 to 1.43) and fibrinogen (?1.45) fragments. Relative risk of having or progressing to eGFR <60 ml/min/1.73 m2 was associated with mucin-1. Partial least-squares analysis confirmed mucin-1 as the strongest urinary marker associated with decreased eGFR, with a score of 2.47 compared with 1.80 for a collagen I fragment as the next contender. Mucin-1 predicted eGFR decline to <60 ml/min/1.73 m2 over and above microalbuminuria (P = 0.011) and retained borderline significance (P = 0.05) when baseline eGFR was accounted for. Discussion: In the general population, mucin-1 subunit ?, an extracellular protein that is shed from renal tubular epithelium, is a novel biomarker associated with renal dysfunction. Twit Text FOAVip A Urinary Fragment of Mucin-1 Subunit Is a Novel Biomarker Associated With Renal Dysfunction in the General Population ????Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=28920100 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28920100 #FOAvip English Wikipedia <ref>{{Cite pmid|28920100}}</ref> A Urinary Fragment of Mucin-1 Subunit ? Is a Novel Biomarker Associated With Renal Dysfunction in the General Population #MMPMID28920100 Zhang ZY; Ravassa S; Pejchinovski M; Yang WY; Zürbig P; López B; Wei FF; Thijs L; Jacobs L; González A; Voigt JU; Verhamme P; Kuznetsova T; Díez J; Mischak H; Staessen JA Kidney Int Rep 2017[Sep]; 2 (5): 811-20 PMID28920100show ga Introduction: Sequencing peptides included in the urinary proteome identifies the parent proteins and may reveal mechanisms underlying the pathophysiology of chronic kidney disease. Methods: In 805 randomly recruited Flemish individuals (50.8% women; mean age, 51.1 years), we determined the estimated glomerular filtration rate (eGFR) from serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. We categorized eGFR according to the National Kidney Foundation Kidney Disease Outcomes Quality Initiative guideline. We analyzed 74 sequenced urinary peptides with a detectable signal in more than 95% of participants. Follow-up measurements of eGFR were available in 597 participants. Results: In multivariable analyses, baseline eGFR decreased (P ? 0.022) with urinary fragments of mucin-1 (standardized association size expressed in ml/min/1.73 m2, ?4.48), collagen III (?2.84), and fibrinogen (?1.70) and was bi-directionally associated (P ? 0.0006) with 2 urinary collagen I fragments (+2.28 and ?3.20). The eGFR changes over 5 years (follow-up minus baseline) resulted in consistent estimates (P ? 0.025) for mucin-1 (?1.85), collagen (?1.37 to 1.43) and fibrinogen (?1.45) fragments. Relative risk of having or progressing to eGFR <60 ml/min/1.73 m2 was associated with mucin-1. Partial least-squares analysis confirmed mucin-1 as the strongest urinary marker associated with decreased eGFR, with a score of 2.47 compared with 1.80 for a collagen I fragment as the next contender. Mucin-1 predicted eGFR decline to <60 ml/min/1.73 m2 over and above microalbuminuria (P = 0.011) and retained borderline significance (P = 0.05) when baseline eGFR was accounted for. Discussion: In the general population, mucin-1 subunit ?, an extracellular protein that is shed from renal tubular epithelium, is a novel biomarker associated with renal dysfunction. äA Urinary Fragment of Mucin-1 Subunit ? Is a Novel Biomarker Associate(epmc).pdf DeepDyve Pubget Overpricing